Guillermo Trujillo Durán (10 February 1878 – 11 February 1967) was a Venezuelan poet and politician. He is also remembered for his work in journalism and film, alongside his brother Manuel Trujillo Durán. He worked as editor for several Maracaibo-based publications and published some collections of poetry. In politics, he first served in the government of Zulia before entering the National Assembly, where he was Vice-President on two occasions.