Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB and BDNF

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB and BDNF

In this study we tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington's Disease (HD). The neurotoxin...

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Bibliographic Details
Main Authors: Puerta, E. (Elena), Hervias, I. (Isabel), Barros-Miñones, L. (Lucía), Jordan, J. (Joaquín), Ricobaraza, A. (Ana), Cuadrado-Tejedor, M. (Mar), Garcia-Osta, A. (Ana), Aguirre, N. (Norberto)
Format: info:eu-repo/semantics/article
Language:eng
Published: ACADEMIC PRESS INC ELSEVIER SCIENCE 2010
Subjects:
3-Nitropropionic acid
BDNF
Calpain
CREB
Excitotoxicity
Huntington's disease
Phosphodiesterase 5
Sildenafil
Vardenafil
Online Access:https://hdl.handle.net/10171/12941

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