Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

Clinical studies suggest that agonists at peroxisome proliferator-activated receptor gamma (PPARγ) may exert beneficial effects in patients with mild-to-moderate Alzheimer's disease (AD), but the mechanism for the potential therapeutic interest of this class of drugs has not yet been elucidated...

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Bibliographic Details
Main Authors: Escribano, L. (Luis), Simon, A.M. (Ana María), Gimeno, E. (Esther), Cuadrado-Tejedor, M. (Mar), Raquel, Garcia-Osta, A. (Ana), Ricobaraza, A. (Ana), Perez-Mediavilla, L.A. (Luis Alberto), Rio, J. (Joaquín) del, Frechilla, D. (Diana)
Format: info:eu-repo/semantics/article
Language:eng
Published: NATURE PUBLISHING GROUP 2010
Subjects:
Alzheimer's disease
amyloid; tau
PPARγ
hippocampus
memory
Online Access:https://hdl.handle.net/10171/12953

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