Axonal branching patterns of nucleus accumbens neurons in the rat
ABSTRACT The patterns of axonal collateralization of nucleus accumbens (Acb) projection neurons were investigated in the rat by means of single-axon tracing techniques using the anterograde tracer biotinylated dextran amine. Seventy-three axons were fully traced, originating from either the co...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Wiley-Blackwell
2010
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| Online Access: | https://hdl.handle.net/10171/13228 |
| _version_ | 1793400144039772160 |
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| author | Tripathi, A. (Anushree) Prensa, L. (Lucía) Cebrian, C. (Carolina) Mengual, E. (Elisa) |
| author_facet | Tripathi, A. (Anushree) Prensa, L. (Lucía) Cebrian, C. (Carolina) Mengual, E. (Elisa) |
| author_sort | Tripathi, A. (Anushree) |
| collection | DSpace |
| description | ABSTRACT
The patterns of axonal collateralization of nucleus
accumbens (Acb) projection neurons were investigated
in the rat by means of single-axon tracing techniques
using the anterograde tracer biotinylated dextran
amine. Seventy-three axons were fully traced, originating
from either the core (AcbC) or shell (AcbSh) compartment,
as assessed by differential calbindin D28kimmunoreactivity.
Axons from AcbC and AcbSh showed
a substantial segregation in their targets; target areas
were either exclusively or preferentially innervated from
AcbC or AcbSh. Axon collaterals in the subthalamic nucleus
were found at higher than expected frequencies;
moreover, these originated exclusively in the dorsal
AcbC. Intercompartmental collaterals were observed
from ventral AcbC axons into AcbSh, and likewise,
interconnections at pallidal and mesencephalic levels
were also observed, although mostly from AcbC axons
toward AcbSh targets, possibly supporting crosstalk
between the two subcircuits at several levels. Cell
somata giving rise to short-range accumbal axons, projecting
to the ventral pallidum (VP), were spatially intermingled
with others, giving rise to long-range axons
that innervated VP and more caudal targets. This anatomical
organization parallels that of the dorsal striatum
and provides the basis for possible dual direct and indirect
actions from a single axon on either individual or
small sets of neurons. J. Comp. Neurol. 518:4649–
4673, 2010. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-13228 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2010 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-132282017-05-14T06:07:45Z Axonal branching patterns of nucleus accumbens neurons in the rat Tripathi, A. (Anushree) Prensa, L. (Lucía) Cebrian, C. (Carolina) Mengual, E. (Elisa) Basal ganglia Limbic system Ventral striatum Axonal collateralization Single axon tracing Reward ABSTRACT The patterns of axonal collateralization of nucleus accumbens (Acb) projection neurons were investigated in the rat by means of single-axon tracing techniques using the anterograde tracer biotinylated dextran amine. Seventy-three axons were fully traced, originating from either the core (AcbC) or shell (AcbSh) compartment, as assessed by differential calbindin D28kimmunoreactivity. Axons from AcbC and AcbSh showed a substantial segregation in their targets; target areas were either exclusively or preferentially innervated from AcbC or AcbSh. Axon collaterals in the subthalamic nucleus were found at higher than expected frequencies; moreover, these originated exclusively in the dorsal AcbC. Intercompartmental collaterals were observed from ventral AcbC axons into AcbSh, and likewise, interconnections at pallidal and mesencephalic levels were also observed, although mostly from AcbC axons toward AcbSh targets, possibly supporting crosstalk between the two subcircuits at several levels. Cell somata giving rise to short-range accumbal axons, projecting to the ventral pallidum (VP), were spatially intermingled with others, giving rise to long-range axons that innervated VP and more caudal targets. This anatomical organization parallels that of the dorsal striatum and provides the basis for possible dual direct and indirect actions from a single axon on either individual or small sets of neurons. J. Comp. Neurol. 518:4649– 4673, 2010. 2010-10-04T11:08:05Z 2010-10-04T11:08:05Z 2010-08-06 info:eu-repo/semantics/article https://hdl.handle.net/10171/13228 eng info:eu-repo/semantics/closedAccess Wiley-Blackwell |
| spellingShingle | Basal ganglia Limbic system Ventral striatum Axonal collateralization Single axon tracing Reward Tripathi, A. (Anushree) Prensa, L. (Lucía) Cebrian, C. (Carolina) Mengual, E. (Elisa) Axonal branching patterns of nucleus accumbens neurons in the rat |
| title | Axonal branching patterns of nucleus accumbens neurons in the rat |
| title_full | Axonal branching patterns of nucleus accumbens neurons in the rat |
| title_fullStr | Axonal branching patterns of nucleus accumbens neurons in the rat |
| title_full_unstemmed | Axonal branching patterns of nucleus accumbens neurons in the rat |
| title_short | Axonal branching patterns of nucleus accumbens neurons in the rat |
| title_sort | axonal branching patterns of nucleus accumbens neurons in the rat |
| topic | Basal ganglia Limbic system Ventral striatum Axonal collateralization Single axon tracing Reward |
| url | https://hdl.handle.net/10171/13228 |
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