Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activiti...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Wiley-Blackwell
2011
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/18591 |
| _version_ | 1793400186500808704 |
|---|---|
| author | Burguete, A. (Asunción) Pontiki, E. (Eleni) Hadjipavlou-Litina, D. (Dimitra) Ancizu, S. (Saioa) Raquel Solano, B. (Beatriz) Moreno-de-Viguri, E. (Elsa) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) |
| author_facet | Burguete, A. (Asunción) Pontiki, E. (Eleni) Hadjipavlou-Litina, D. (Dimitra) Ancizu, S. (Saioa) Raquel Solano, B. (Beatriz) Moreno-de-Viguri, E. (Elsa) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) |
| author_sort | Burguete, A. (Asunción) |
| collection | DSpace |
| description | We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase. Two of the best lipoxygenase inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-18591 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2011 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-185912022-11-28T11:33:53Z Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents Burguete, A. (Asunción) Pontiki, E. (Eleni) Hadjipavlou-Litina, D. (Dimitra) Ancizu, S. (Saioa) Raquel Solano, B. (Beatriz) Moreno-de-Viguri, E. (Elsa) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase. Two of the best lipoxygenase inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug. 2011-06-21T07:23:02Z 2011-06-21T07:23:02Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/18591 eng info:eu-repo/semantics/openAccess application/pdf Wiley-Blackwell |
| spellingShingle | Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase Burguete, A. (Asunción) Pontiki, E. (Eleni) Hadjipavlou-Litina, D. (Dimitra) Ancizu, S. (Saioa) Raquel Solano, B. (Beatriz) Moreno-de-Viguri, E. (Elsa) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title | Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title_full | Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title_fullStr | Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title_full_unstemmed | Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title_short | Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| title_sort | synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents |
| topic | Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase |
| url | https://hdl.handle.net/10171/18591 |
| work_keys_str_mv | AT burgueteaasuncion synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT pontikieeleni synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT hadjipavloulitinaddimitra synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT ancizussaioa synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT raquel synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT solanobbeatriz synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT morenodevigurieelsa synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT torreseenrique synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT perezsilanesssilvia synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT aldanaiignacio synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents AT mongeaantonio synthesisandbiologicalevaluationofnewquinoxalinederivativesasantioxidantandantiinflammatoryagents |