Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents

Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents

We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activiti...

Full description

Bibliographic Details
Main Authors:	Burguete, A. (Asunción), Pontiki, E. (Eleni), Hadjipavlou-Litina, D. (Dimitra), Ancizu, S. (Saioa), Raquel, Solano, B. (Beatriz), Moreno-de-Viguri, E. (Elsa), Torres, E. (Enrique), Pérez-Silanes, S. (Silvia), Aldana, I. (Ignacio), Monge, A. (Antonio)
Format:	info:eu-repo/semantics/article
Language:	eng
Published:	Wiley-Blackwell 2011
Subjects:	Quinoxaline derivatives Anti-inflammatory agents 1,4-di-N-oxide derivatives Soybean lipoxygenase
Online Access:	https://hdl.handle.net/10171/18591

Similar Items

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents
by: Torres, E. (Enrique), et al.
Published: (2011)

Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis
by: Vicente, E. (Esther), et al.
Published: (2011)

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
by: Aldana, I. (Ignacio), et al.
Published: (2014)

New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
by: Barea, C. (Carlos), et al.
Published: (2013)

Cyclic voltammetric study of some anti-Chagas-active 1,4-dioxidoquinoxalin-2-yl ketone derivatives
by: Crawford, P.W. (Philip W.), et al.
Published: (2014)

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents
by: Pérez-Silanes, S. (Silvia), et al.
Published: (2014)

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti- Mycobacterium tuberculosis agents.
by: Monge, A. (Antonio), et al.
Published: (2014)

Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives.
by: Monge, A. (Antonio), et al.
Published: (2014)

Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.
by: Vicente, E. (Esther), et al.
Published: (2012)

Primaquine–quinoxaline 1,4‑di‑N‑oxide hybrids with action on the exo‑erythrocytic forms of Plasmodium induce their efect by the production of reactive oxygen species
by: Bonilla‑Ramírez, L. (Leonardo), et al.
Published: (2022)

Synthesis and Preclinical Development of novel Organoselenium compounds as Multi-Target and Bioactive Agents
by: Astráin-Redín, N. (Nora), et al.
Published: (2023)

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
by: Barea, C. (Carlos), et al.
Published: (2012)

Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives
by: Vicente, E. (Esther), et al.
Published: (2012)

An Efficient One-Pot Protocol for the Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones Using Metallophthalocyanines (MPcs) as Potent Heterogeneous Catalysts: Synthesis, Characterization, Aggregation and Antimicrobial Activity
by: Hamdi, Naceur, et al.
Published: (2020)

Design and synthesis of new selenoderivatives with biomedical applications
by: Ramos-Inza, S. (Sandra), et al.
Published: (2023)

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis
by: Vicente, E. (Esther), et al.
Published: (2013)

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity
by: Pérez-Silanes, S. (Silvia), et al.
Published: (2016)

An Extension of the Concept of Derivative: Its Application to Intertemporal Choice
by: Cruz Rambaud, Salvador, et al.
Published: (2020)

Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis
by: Santivañez-Veliz, M. (Mery), et al.
Published: (2016)

Asymptotics of the L2 norm of derivatives of OPUC
by: Martínez-Finkelshtein, Andrei, et al.
Published: (2012)

Unexpected reduction of ethyl 3-phenylquinoxaline-2- carboxylate 1,4-di-N-oxide derivatives by amines.
by: Lima, L.M. (Lidia M.), et al.
Published: (2012)

Aplicación de software matemático DERIVE, para el logro de aprendizajes en aplicaciones del cálculo diferencial e integral, en estudiantes universitarios
by: Muñoz Suárez, Manuel Antonio
Published: (2018)

Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.
by: Alguacil Alarcón, Andrés, et al.
Published: (2024)

Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort
by: Ramallal, R. (Raul), et al.
Published: (2015)

Análisis experimental de las condiciones que influyen en la aparición del comportamiento humorístico
by: Bebber, Matheus
Published: (2022)

Synthesis of quinoxaline 1,4-di-N-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures
by: Gomez-Caro, L.C. (Lilia C.), et al.
Published: (2013)

The outer membranes of Brucella spp. are not barriers to hydrophobic permeants
by: Martinez-de-Tejada, G. (Guillermo), et al.
Published: (2013)

Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.
by: Moreno-de-Viguri, E. (Elsa), et al.
Published: (2012)

New 1-aryl-3-substituted propanol derivatives as antimalarial agents
by: Pérez-Silanes, S. (Silvia), et al.
Published: (2012)

Dietary tryptophan depletion alters the faecal bacterial community structure of compulsive drinker rats in schedule-induced polydipsia
by: Merchán Carrillo, Ana María, et al.
Published: (2024)

Problemas de cálculo diferencial: cuestiones, ejercicios y tratamiento en DERIVE

New quinoxaline 1,4-di-N-oxide derivatives: Trypanosomaticidal activities and enzyme docking simulation
by: Estevez, Y. (Yannick), et al.
Published: (2014)

Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects
by: Navas, Arturo, et al.
Published: (2020)

Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach
by: Flores-Mateo, G. (Gemma), et al.
Published: (2014)

Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population
by: Marti-del-Moral, A. (Amelia), et al.
Published: (2014)

New quinoxaline and indole derivatives as MT1 and MT2 receptor agonists
by: Ancizu, S. (Saioa), et al.
Published: (2014)

Dietary inflammatory index and incidence of cardiovascular disease in the PREDIMED study
by: PREDIMED, et al.
Published: (2015)

Partially halogenated chlorofluorocarbon: ethane derivativesChlorofluorocarbons, partially halogenated: ethane derivatives)

Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives
by: Burguete, A. (Asunción), et al.
Published: (2015)

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds
by: Zentar, Houda, et al.
Published: (2022)