Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective...

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Bibliographic Details
Main Authors: Berrade, L. (Luis), Aisa, B. (Bárbara), Ramirez, M.J. (María Javier), Galiano, S. (Silvia), Guccione, S. (S.), Moltzau, L.R. (Lise Roman), Levy, F.O. (Finn Olav), Nicoletti, F. (Ferdinando), Battaglia, G. (G.), Molinaro, G. (Gemma), Aldana, I. (Ignacio), Monge, A. (Antonio), Pérez-Silanes, S. (Silvia)
Format: info:eu-repo/semantics/article
Language:eng
Published: American Chemical Society 2011
Subjects:
Depression
Benzo[b]thiophene
Serotonin
5-HT7 receptors
SERT
Dual compounds
Forced swimming test
Fluoxetine
Online Access:https://hdl.handle.net/10171/18726
Description
Summary:We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

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