Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action
We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
American Chemical Society
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/18726 |
| _version_ | 1793400186963230720 |
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| author | Berrade, L. (Luis) Aisa, B. (Bárbara) Ramirez, M.J. (María Javier) Galiano, S. (Silvia) Guccione, S. (S.) Moltzau, L.R. (Lise Roman) Levy, F.O. (Finn Olav) Nicoletti, F. (Ferdinando) Battaglia, G. (G.) Molinaro, G. (Gemma) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) |
| author_facet | Berrade, L. (Luis) Aisa, B. (Bárbara) Ramirez, M.J. (María Javier) Galiano, S. (Silvia) Guccione, S. (S.) Moltzau, L.R. (Lise Roman) Levy, F.O. (Finn Olav) Nicoletti, F. (Ferdinando) Battaglia, G. (G.) Molinaro, G. (Gemma) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) |
| author_sort | Berrade, L. (Luis) |
| collection | DSpace |
| description | We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-18726 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2011 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-187262020-03-03T20:47:48Z Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action Berrade, L. (Luis) Aisa, B. (Bárbara) Ramirez, M.J. (María Javier) Galiano, S. (Silvia) Guccione, S. (S.) Moltzau, L.R. (Lise Roman) Levy, F.O. (Finn Olav) Nicoletti, F. (Ferdinando) Battaglia, G. (G.) Molinaro, G. (Gemma) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) Depression Benzo[b]thiophene Serotonin 5-HT7 receptors SERT Dual compounds Forced swimming test Fluoxetine We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action. 2011-07-04T12:28:06Z 2011-07-04T12:28:06Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/18726 eng info:eu-repo/semantics/openAccess application/pdf American Chemical Society |
| spellingShingle | Depression Benzo[b]thiophene Serotonin 5-HT7 receptors SERT Dual compounds Forced swimming test Fluoxetine Berrade, L. (Luis) Aisa, B. (Bárbara) Ramirez, M.J. (María Javier) Galiano, S. (Silvia) Guccione, S. (S.) Moltzau, L.R. (Lise Roman) Levy, F.O. (Finn Olav) Nicoletti, F. (Ferdinando) Battaglia, G. (G.) Molinaro, G. (Gemma) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title_full | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title_fullStr | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title_full_unstemmed | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title_short | Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action |
| title_sort | novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action |
| topic | Depression Benzo[b]thiophene Serotonin 5-HT7 receptors SERT Dual compounds Forced swimming test Fluoxetine |
| url | https://hdl.handle.net/10171/18726 |
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