Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis
New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal)...
| Main Authors: | , , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Bentham Science Publishers
2011
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| Online Access: | https://hdl.handle.net/10171/18728 |
| _version_ | 1793400187200208896 |
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| author | Vicente, E. (Esther) Raquel Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Goldman, R.C. (Robert C.) Monge, A. (Antonio) Solano, B. (Beatriz) Burguete, A. (Asunción) Ancizu, S. (Saioa) Zarranz, B. (Belén) Jaso, A. (Andrés) Marin, A. (Adoración) |
| author_facet | Vicente, E. (Esther) Raquel Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Goldman, R.C. (Robert C.) Monge, A. (Antonio) Solano, B. (Beatriz) Burguete, A. (Asunción) Ancizu, S. (Saioa) Zarranz, B. (Belén) Jaso, A. (Andrés) Marin, A. (Adoración) |
| author_sort | Vicente, E. (Esther) |
| collection | DSpace |
| description | New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal) and evaluation of their medicinal chemistry is still in progress. In this review we report the properties and the recent developments of quinoxaline 1,4-di-N-oxide derivatives as potential anti-tuberculosis agents. Specific agents are reviewed that have excellent antitubercular drug properties, are active on drug resistant strains and non-replicating mycobacteria. The properties of select analogs that have in vivo activity in the low dose aerosol infection model in mice will be reviewed. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-18728 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2011 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-187282022-11-28T11:33:54Z Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis Vicente, E. (Esther) Raquel Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Goldman, R.C. (Robert C.) Monge, A. (Antonio) Solano, B. (Beatriz) Burguete, A. (Asunción) Ancizu, S. (Saioa) Zarranz, B. (Belén) Jaso, A. (Andrés) Marin, A. (Adoración) Tuberculosis Quinoxaline 1,4-di-N-oxide Mycobacterium New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal) and evaluation of their medicinal chemistry is still in progress. In this review we report the properties and the recent developments of quinoxaline 1,4-di-N-oxide derivatives as potential anti-tuberculosis agents. Specific agents are reviewed that have excellent antitubercular drug properties, are active on drug resistant strains and non-replicating mycobacteria. The properties of select analogs that have in vivo activity in the low dose aerosol infection model in mice will be reviewed. 2011-07-04T12:41:12Z 2011-07-04T12:41:12Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/18728 eng info:eu-repo/semantics/openAccess application/pdf Bentham Science Publishers |
| spellingShingle | Tuberculosis Quinoxaline 1,4-di-N-oxide Mycobacterium Vicente, E. (Esther) Raquel Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Goldman, R.C. (Robert C.) Monge, A. (Antonio) Solano, B. (Beatriz) Burguete, A. (Asunción) Ancizu, S. (Saioa) Zarranz, B. (Belén) Jaso, A. (Andrés) Marin, A. (Adoración) Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title | Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title_full | Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title_fullStr | Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title_full_unstemmed | Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title_short | Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis |
| title_sort | quinoxaline 1,4-di-n-oxide and the potential for treating tuberculosis |
| topic | Tuberculosis Quinoxaline 1,4-di-N-oxide Mycobacterium |
| url | https://hdl.handle.net/10171/18728 |
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