New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents
The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/18732 |
| _version_ | 1793400187909046272 |
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| author | Torres, E. (Enrique) Moreno-de-Viguri, E. (Elsa) Ancizu, S. (Saioa) Barea, C. (Carlos) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) |
| author_facet | Torres, E. (Enrique) Moreno-de-Viguri, E. (Elsa) Ancizu, S. (Saioa) Barea, C. (Carlos) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) |
| author_sort | Torres, E. (Enrique) |
| collection | DSpace |
| description | The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-18732 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2011 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-187322020-03-04T02:37:55Z New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents Torres, E. (Enrique) Moreno-de-Viguri, E. (Elsa) Ancizu, S. (Saioa) Barea, C. (Carlos) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research. 2011-07-04T18:19:04Z 2011-07-04T18:19:04Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/18732 eng info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness Torres, E. (Enrique) Moreno-de-Viguri, E. (Elsa) Ancizu, S. (Saioa) Barea, C. (Carlos) Aldana, I. (Ignacio) Monge, A. (Antonio) Pérez-Silanes, S. (Silvia) New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_full | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_fullStr | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_full_unstemmed | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_short | New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_sort | new 1,4-di-n-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-mycobacterieum tuberculosis agents |
| topic | Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness |
| url | https://hdl.handle.net/10171/18732 |
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