Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice

Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice

Objective: To study the toxicity and activity of two new amphotericin B formulations: poly(ε-caprolactone) nanospheres coated with poloxamer 188 (AmB-NP) and mixed micelles with the same surfactant (AmB-MM). Materials and methods: The toxicity of these formulations was evaluated in erythrocytes, J...

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Bibliographic Details
Main Authors: Espuelas, S. (Socorro), Legrand, P. (P.), Campanero, M.A. (Miguel Angel), Appel, M. (M.), Cheron, M. (M.), Gamazo, C. (Carlos), Barratt, G. (G.), Irache, J.M. (Juan Manuel)
Format: info:eu-repo/semantics/article
Language:eng
Published: Oxford University Press 2011
Subjects:
Amphotericin B
Candida albicans
Micelles
Nanospheres
Poloxamer
Online Access:https://hdl.handle.net/10171/19187

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