Chemical and biological factors in the control Brucella and Brucellosis
Brucellosis is a highly contagious bacterial zoonosis that affects millions of people worldwide. Brucella is highly infectious, especially when aerosolized. The infection induces severe protracted diseases, which are both debilitating and incapacitating, hence, Brucella melitensis has been considere...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Bentham Open
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/20802 |
| _version_ | 1793400196251516928 |
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| author | Gamazo, C. (Carlos) Lecaroz, M.C. (María Concepción) Prior, S. (Sandra) Vitas, A.I. (Ana Isabel) Campanero, M.A. (Miguel Angel) Irache, J.M. (Juan Manuel) Blanco-Prieto, M.J. (María José) |
| author_facet | Gamazo, C. (Carlos) Lecaroz, M.C. (María Concepción) Prior, S. (Sandra) Vitas, A.I. (Ana Isabel) Campanero, M.A. (Miguel Angel) Irache, J.M. (Juan Manuel) Blanco-Prieto, M.J. (María José) |
| author_sort | Gamazo, C. (Carlos) |
| collection | DSpace |
| description | Brucellosis is a highly contagious bacterial zoonosis that affects millions of people worldwide. Brucella is highly infectious, especially when aerosolized. The infection induces severe protracted diseases, which are both debilitating and incapacitating, hence, Brucella melitensis has been considered a potential biological warfare agent. In the battle against Brucella, it is crucial to know its chemical-structure and biochemistry-metabolic characteristics. It is well known that Brucella, as well as many other intracellular bacterial pathogens, has evolved to survive and even proliferate within monocytes and macrophages cells. Depending on the route of entry (complement, Fc, lectin or fibronectin receptors), the fate of the bacteria will vary; it may even segregate from the endocytic route towards the endoplasmic reticulum. This intracellular “non regular” behaviour of Brucella makes treatment difficult. Most antibiotics, although effective in vitro, do not actively pass through cellular membranes, or, once inside, may not reach the discrete intracellular niche where the bacteria is hidden. Therefore, complete eradication of the microorganisms is difficult to achieve, and the incidence of relapses is rather high. Taking these data into consideration, this review will evaluate the past, current and new trends in the control of brucellosis, paying special attention to the drug delivery systems as potential vectors for targeting these intracellular sites where the organisms are located. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-20802 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Bentham Open |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-208022020-03-23T17:31:39Z Chemical and biological factors in the control Brucella and Brucellosis Gamazo, C. (Carlos) Lecaroz, M.C. (María Concepción) Prior, S. (Sandra) Vitas, A.I. (Ana Isabel) Campanero, M.A. (Miguel Angel) Irache, J.M. (Juan Manuel) Blanco-Prieto, M.J. (María José) Brucella Brucellosis Chemotherapy Gentamicin Drug delivery systems Brucellosis is a highly contagious bacterial zoonosis that affects millions of people worldwide. Brucella is highly infectious, especially when aerosolized. The infection induces severe protracted diseases, which are both debilitating and incapacitating, hence, Brucella melitensis has been considered a potential biological warfare agent. In the battle against Brucella, it is crucial to know its chemical-structure and biochemistry-metabolic characteristics. It is well known that Brucella, as well as many other intracellular bacterial pathogens, has evolved to survive and even proliferate within monocytes and macrophages cells. Depending on the route of entry (complement, Fc, lectin or fibronectin receptors), the fate of the bacteria will vary; it may even segregate from the endocytic route towards the endoplasmic reticulum. This intracellular “non regular” behaviour of Brucella makes treatment difficult. Most antibiotics, although effective in vitro, do not actively pass through cellular membranes, or, once inside, may not reach the discrete intracellular niche where the bacteria is hidden. Therefore, complete eradication of the microorganisms is difficult to achieve, and the incidence of relapses is rather high. Taking these data into consideration, this review will evaluate the past, current and new trends in the control of brucellosis, paying special attention to the drug delivery systems as potential vectors for targeting these intracellular sites where the organisms are located. 2012-02-10T11:55:52Z 2012-02-10T11:55:52Z 2006 info:eu-repo/semantics/article https://hdl.handle.net/10171/20802 eng http://www.benthamdirect.org/pages/content.php?CDD/2006/00000003/00000004/003AP.SGM info:eu-repo/semantics/openAccess application/pdf Bentham Open |
| spellingShingle | Brucella Brucellosis Chemotherapy Gentamicin Drug delivery systems Gamazo, C. (Carlos) Lecaroz, M.C. (María Concepción) Prior, S. (Sandra) Vitas, A.I. (Ana Isabel) Campanero, M.A. (Miguel Angel) Irache, J.M. (Juan Manuel) Blanco-Prieto, M.J. (María José) Chemical and biological factors in the control Brucella and Brucellosis |
| title | Chemical and biological factors in the control Brucella and Brucellosis |
| title_full | Chemical and biological factors in the control Brucella and Brucellosis |
| title_fullStr | Chemical and biological factors in the control Brucella and Brucellosis |
| title_full_unstemmed | Chemical and biological factors in the control Brucella and Brucellosis |
| title_short | Chemical and biological factors in the control Brucella and Brucellosis |
| title_sort | chemical and biological factors in the control brucella and brucellosis |
| topic | Brucella Brucellosis Chemotherapy Gentamicin Drug delivery systems |
| url | https://hdl.handle.net/10171/20802 |
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