Complement activation in non-small cell lung cáncer and its effect on tumor progresión
HYPOTHESIS The hypothesis of the present work is that tumor cells express on their surface tumorassociated antigens that have the potential to activate the complement system. At the same time, tumor cells have developed mechanisms that make them resistant to complement cytotoxic effects. The sub...
| Main Authors: | , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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Servicio de Publicaciones de la Universidad de Navarra
2012
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| Online Access: | https://hdl.handle.net/10171/21154 |
| _version_ | 1793400541036937216 |
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| author | Corrales, L. (Leticia) Pio, R. (Rubén) |
| author_facet | Corrales, L. (Leticia) Pio, R. (Rubén) |
| author_sort | Corrales, L. (Leticia) |
| collection | DSpace |
| description | HYPOTHESIS
The hypothesis of the present work is that tumor cells express on their surface tumorassociated
antigens that have the potential to activate the complement system. At the
same time, tumor cells have developed mechanisms that make them resistant to
complement cytotoxic effects. The subsequent effects of complement activation on
complement-resistant cancer cells play a pivotal role in the development of malignant
features, ending in tumor progression.
OBJECTIVES
1. To study complement activation by the alternative and classical pathways on
non-small cell lung cancer (NSCLC) cells and normal bronchial epithelial cells.
2. To study the expression, at the mRNA and protein levels, of the main
complement inhibitory proteins in NSCLC and normal bronchial epithelial cells.
3. To study the role of complement in a syngeneic mouse model of lung cancer,
with special interest in tumor-associated characteristics of the microenvironment such as
angiogenesis and immunosuppression.
4. To evaluate the tumor-promoting effects of complement on NSCLC cells. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-21154 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Servicio de Publicaciones de la Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-211542021-07-06T10:46:33Z Complement activation in non-small cell lung cáncer and its effect on tumor progresión Corrales, L. (Leticia) Pio, R. (Rubén) Cáncer Tumores Células Materias Investigacion::Ciencias de la Salud::Oncología HYPOTHESIS The hypothesis of the present work is that tumor cells express on their surface tumorassociated antigens that have the potential to activate the complement system. At the same time, tumor cells have developed mechanisms that make them resistant to complement cytotoxic effects. The subsequent effects of complement activation on complement-resistant cancer cells play a pivotal role in the development of malignant features, ending in tumor progression. OBJECTIVES 1. To study complement activation by the alternative and classical pathways on non-small cell lung cancer (NSCLC) cells and normal bronchial epithelial cells. 2. To study the expression, at the mRNA and protein levels, of the main complement inhibitory proteins in NSCLC and normal bronchial epithelial cells. 3. To study the role of complement in a syngeneic mouse model of lung cancer, with special interest in tumor-associated characteristics of the microenvironment such as angiogenesis and immunosuppression. 4. To evaluate the tumor-promoting effects of complement on NSCLC cells. 2012-03-15T09:35:09Z 2012-03-15T09:35:09Z 2012 2011-03-18 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/21154 eng info:eu-repo/semantics/openAccess application/pdf Servicio de Publicaciones de la Universidad de Navarra |
| spellingShingle | Cáncer Tumores Células Materias Investigacion::Ciencias de la Salud::Oncología Corrales, L. (Leticia) Pio, R. (Rubén) Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title | Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title_full | Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title_fullStr | Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title_full_unstemmed | Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title_short | Complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| title_sort | complement activation in non-small cell lung cáncer and its effect on tumor progresión |
| topic | Cáncer Tumores Células Materias Investigacion::Ciencias de la Salud::Oncología |
| url | https://hdl.handle.net/10171/21154 |
| work_keys_str_mv | AT corraleslleticia complementactivationinnonsmallcelllungcanceranditseffectontumorprogresion AT piorruben complementactivationinnonsmallcelllungcanceranditseffectontumorprogresion |