Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C
BACKGROUND & AIMS: In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome. METHODS: One hundred eighty-one pati...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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WB Saunders
2012
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| Online Access: | https://hdl.handle.net/10171/21677 |
| _version_ | 1793400098518990848 |
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| author | Gavier, B. (B.) Martinez-Gonzalez, M.A. (Miguel Ángel) Riezu-Boj, J.I. (José Ignacio) Lasarte, J.J. (Juan José) Garcia, N. (Nicolás) Civeira, M.P. (María Pilar) Prieto, J. (Jesús) |
| author_facet | Gavier, B. (B.) Martinez-Gonzalez, M.A. (Miguel Ángel) Riezu-Boj, J.I. (José Ignacio) Lasarte, J.J. (Juan José) Garcia, N. (Nicolás) Civeira, M.P. (María Pilar) Prieto, J. (Jesús) |
| author_sort | Gavier, B. (B.) |
| collection | DSpace |
| description | BACKGROUND & AIMS:
In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome.
METHODS:
One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 months) were studied. Viremia and aminotransferase levels at the first and third months of therapy as well as 10 pretreatment variables were assessed as potential independent predictors of sustained response to treatment.
RESULTS:
Sustained response occurred in 51 patients (28%). At month 1 of treatment, viral persistence accurately predicted nonresponse (predictive value, 95.3; 95% confidence interval, 86.0-98.8; P < 0.0001). Independent predictors of sustained response were undetectable viremia at the first month of therapy (P < 0.001), undetectable viremia at the third month (P < 0.001), younger age (P = 0.006), nonsporadic infection (P = 0.012), and higher pretreatment aspartate aminotransferase levels (P = 0.032). In patients who cleared HCV RNA at month 1 of therapy, the predicted probability of sustained response averaged 70% for those younger than 30 years and diminished by 10% for each decade of age.
CONCLUSIONS:
Failure to clear HCV RNA at month 1 of treatment is strongly and independently associated with a very low probability of a sustained response to interferon. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-21677 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | WB Saunders |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-216772022-06-29T09:41:38Z Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C Gavier, B. (B.) Martinez-Gonzalez, M.A. (Miguel Ángel) Riezu-Boj, J.I. (José Ignacio) Lasarte, J.J. (Juan José) Garcia, N. (Nicolás) Civeira, M.P. (María Pilar) Prieto, J. (Jesús) Antiviral Agents/therapeutic use Hepatitis C/therapy Interferon-alpha/therapeutic use Viremia/therapy BACKGROUND & AIMS: In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome. METHODS: One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 months) were studied. Viremia and aminotransferase levels at the first and third months of therapy as well as 10 pretreatment variables were assessed as potential independent predictors of sustained response to treatment. RESULTS: Sustained response occurred in 51 patients (28%). At month 1 of treatment, viral persistence accurately predicted nonresponse (predictive value, 95.3; 95% confidence interval, 86.0-98.8; P < 0.0001). Independent predictors of sustained response were undetectable viremia at the first month of therapy (P < 0.001), undetectable viremia at the third month (P < 0.001), younger age (P = 0.006), nonsporadic infection (P = 0.012), and higher pretreatment aspartate aminotransferase levels (P = 0.032). In patients who cleared HCV RNA at month 1 of therapy, the predicted probability of sustained response averaged 70% for those younger than 30 years and diminished by 10% for each decade of age. CONCLUSIONS: Failure to clear HCV RNA at month 1 of treatment is strongly and independently associated with a very low probability of a sustained response to interferon. 2012-04-17T14:41:24Z 2012-04-17T14:41:24Z 1997 info:eu-repo/semantics/article https://hdl.handle.net/10171/21677 eng http://www.sciencedirect.com/science/article/pii/S0016508597005325 info:eu-repo/semantics/openAccess application/pdf WB Saunders |
| spellingShingle | Antiviral Agents/therapeutic use Hepatitis C/therapy Interferon-alpha/therapeutic use Viremia/therapy Gavier, B. (B.) Martinez-Gonzalez, M.A. (Miguel Ángel) Riezu-Boj, J.I. (José Ignacio) Lasarte, J.J. (Juan José) Garcia, N. (Nicolás) Civeira, M.P. (María Pilar) Prieto, J. (Jesús) Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title | Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title_full | Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title_fullStr | Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title_full_unstemmed | Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title_short | Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C |
| title_sort | viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis c |
| topic | Antiviral Agents/therapeutic use Hepatitis C/therapy Interferon-alpha/therapeutic use Viremia/therapy |
| url | https://hdl.handle.net/10171/21677 |
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