TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls
OBJECTIVE: A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk. PATIENTS: Obese (n=165) and control subjects (n=165) matc...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Informa Healthcare
2012
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| Online Access: | https://hdl.handle.net/10171/21711 |
| _version_ | 1793400074185736192 |
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| author | Ochoa, M.C. (María Carmen) Moreno-Aliaga, M. J. (María Jesús) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Marti-del-Moral, A. (Amelia) Grupo de Estudio Navarro de la Obesidad Infantil (GENOI) |
| author_facet | Ochoa, M.C. (María Carmen) Moreno-Aliaga, M. J. (María Jesús) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Marti-del-Moral, A. (Amelia) Grupo de Estudio Navarro de la Obesidad Infantil (GENOI) |
| author_sort | Ochoa, M.C. (María Carmen) |
| collection | DSpace |
| description | OBJECTIVE: A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk. PATIENTS: Obese (n=165) and control subjects (n=165) matched by sex and age were recruited and classified according to Spanish reference data. Results. Using conditional logistic regression, we calculated the obesity risk linked to the polymorphism. A statistically significant association was found for 27Glu carrier allele girls (OR = 1.95; 95% CI = 1.02-3.70), but no association was apparent among boys. In the fully adjusted model, the odds ratio for obesity linked to the genotype Glu27Glu in the female population rose to 4.84 (95% CI = 1.37-17.10). Moreover, we found a significant negative interaction between hours of TV watching and the Gln27Glu polymorphism for obesity risk in girls. Surprisingly, among 27Glu carrier subjects, even girls with a low level of TV watching ( < 12.5 h/week) had a high obesity risk (OR = 4.60; 95% CI = 1.01-20.02), which was not very different to the odds ratio values for sedentary girls carrying the 27 Glu allele watching TV more than 12.5 h/week (OR = 6.05; 95% CI = 1.31-27.71). Conclusion. A higher risk of obesity was found for girls carrying the 27Glu allele of the ADRB2 gene even when they spent less than 12.5 h/week watchin |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-21711 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Informa Healthcare |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-217112024-01-24T08:58:35Z TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls Ochoa, M.C. (María Carmen) Moreno-Aliaga, M. J. (María Jesús) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Marti-del-Moral, A. (Amelia) Grupo de Estudio Navarro de la Obesidad Infantil (GENOI) ADRB2 Gln27Glu polymorphism Obesity risk Television Children OBJECTIVE: A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk. PATIENTS: Obese (n=165) and control subjects (n=165) matched by sex and age were recruited and classified according to Spanish reference data. Results. Using conditional logistic regression, we calculated the obesity risk linked to the polymorphism. A statistically significant association was found for 27Glu carrier allele girls (OR = 1.95; 95% CI = 1.02-3.70), but no association was apparent among boys. In the fully adjusted model, the odds ratio for obesity linked to the genotype Glu27Glu in the female population rose to 4.84 (95% CI = 1.37-17.10). Moreover, we found a significant negative interaction between hours of TV watching and the Gln27Glu polymorphism for obesity risk in girls. Surprisingly, among 27Glu carrier subjects, even girls with a low level of TV watching ( < 12.5 h/week) had a high obesity risk (OR = 4.60; 95% CI = 1.01-20.02), which was not very different to the odds ratio values for sedentary girls carrying the 27 Glu allele watching TV more than 12.5 h/week (OR = 6.05; 95% CI = 1.31-27.71). Conclusion. A higher risk of obesity was found for girls carrying the 27Glu allele of the ADRB2 gene even when they spent less than 12.5 h/week watchin 2012-04-21T17:47:11Z 2012-04-21T17:47:11Z 2006 info:eu-repo/semantics/article https://hdl.handle.net/10171/21711 eng info:eu-repo/semantics/openAccess application/pdf Informa Healthcare |
| spellingShingle | ADRB2 Gln27Glu polymorphism Obesity risk Television Children Ochoa, M.C. (María Carmen) Moreno-Aliaga, M. J. (María Jesús) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Marti-del-Moral, A. (Amelia) Grupo de Estudio Navarro de la Obesidad Infantil (GENOI) TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title | TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title_full | TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title_fullStr | TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title_full_unstemmed | TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title_short | TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls |
| title_sort | tv watching modifies obesity risk linked to the 27glu polymorphism of the adrb2 gene in girls |
| topic | ADRB2 Gln27Glu polymorphism Obesity risk Television Children |
| url | https://hdl.handle.net/10171/21711 |
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