Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors
OBJECTIVES: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothrombotic-proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have asses...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/22243 |
| _version_ | 1793400098786377728 |
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| author | Gomez-Ambrosi, J. (Javier) Salvador, J. (Javier) Paramo, J.A. (José Antonio) Orbe, J. (Josune) Irala, J. (Jokin) de Diez-Caballero, A. (Alberto) Gil, M.J. (María José) Álvarez-Cienfuegos, J. (Javier) Frühbeck, G. (Gema) |
| author_facet | Gomez-Ambrosi, J. (Javier) Salvador, J. (Javier) Paramo, J.A. (José Antonio) Orbe, J. (Josune) Irala, J. (Jokin) de Diez-Caballero, A. (Alberto) Gil, M.J. (María José) Álvarez-Cienfuegos, J. (Javier) Frühbeck, G. (Gema) |
| author_sort | Gomez-Ambrosi, J. (Javier) |
| collection | DSpace |
| description | OBJECTIVES: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothrombotic-proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations.
DESIGN AND METHODS: Twenty-five men aged 49.6 +/- 12.7 yr (mean +/- SD) underwent whole-body air displacement plethysmography (Bod-Pod(R)) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out.
RESULTS: Obese subjects had higher levels as compared to controls of BF (37.5 +/- 5.1 vs. 26.0 +/- 6.6, p < 0.01), fibrinogen (3.30 +/- 0.43 vs. 2.67 +/- 0.11, p < 0.01), vWF (136.4 +/- 50.4% vs. 81.6 +/- 12.6%, p < 0.05), and leptin (17.6 +/- 8.7 vs. 6.2 +/- 3.3, p < 0.01), lower concentrations of HDL-cholesterol (1.09 +/- 0.20 vs. 1.51 +/- 0.10, p < 0.001) and lower QUICKI (1/[log(Ins(0)) + log(Glu(0))]) (0.31 +/- 0.03 vs. 0.34 +/- 0.02, p < 0.05). No significant changes were observed in CRP (5.7 +/- 3.4 vs. 3.8 +/- 1.6, p = 0.327) and homocysteine (9.4 +/- 4.2 vs. 8.3 +/- 0.9, p = 0.749). A positive correlation was observed between BF and fibrinogen (r = 0.67, p = 0.0003). Plasma leptin concentrations were correlated with fibrinogen (r = 0.71, p = 0.0001) and CRP (r = 0.43, p = 0.044). After adjustment for BF leptin emerged as a significant predictor of fibrinogen (beta = 0.47, p = 0.023; R(2) = 0.59, p < 0.001). QUICKI was positively correlated with HDL-cholesterol (r = 0.59, p = 0.010) and negatively with fibrinogen (r = -0.53, p = 0.025), CRP (r = -0.52, p = 0.028) and vWF (r = -0.56, p = 0.013).
CONCLUSIONS: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22243 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-222432021-10-19T05:18:44Z Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors Gomez-Ambrosi, J. (Javier) Salvador, J. (Javier) Paramo, J.A. (José Antonio) Orbe, J. (Josune) Irala, J. (Jokin) de Diez-Caballero, A. (Alberto) Gil, M.J. (María José) Álvarez-Cienfuegos, J. (Javier) Frühbeck, G. (Gema) Obesity Cardiovascular risk Leptin Fibrinogen Insulin sensitivity OBJECTIVES: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothrombotic-proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. DESIGN AND METHODS: Twenty-five men aged 49.6 +/- 12.7 yr (mean +/- SD) underwent whole-body air displacement plethysmography (Bod-Pod(R)) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. RESULTS: Obese subjects had higher levels as compared to controls of BF (37.5 +/- 5.1 vs. 26.0 +/- 6.6, p < 0.01), fibrinogen (3.30 +/- 0.43 vs. 2.67 +/- 0.11, p < 0.01), vWF (136.4 +/- 50.4% vs. 81.6 +/- 12.6%, p < 0.05), and leptin (17.6 +/- 8.7 vs. 6.2 +/- 3.3, p < 0.01), lower concentrations of HDL-cholesterol (1.09 +/- 0.20 vs. 1.51 +/- 0.10, p < 0.001) and lower QUICKI (1/[log(Ins(0)) + log(Glu(0))]) (0.31 +/- 0.03 vs. 0.34 +/- 0.02, p < 0.05). No significant changes were observed in CRP (5.7 +/- 3.4 vs. 3.8 +/- 1.6, p = 0.327) and homocysteine (9.4 +/- 4.2 vs. 8.3 +/- 0.9, p = 0.749). A positive correlation was observed between BF and fibrinogen (r = 0.67, p = 0.0003). Plasma leptin concentrations were correlated with fibrinogen (r = 0.71, p = 0.0001) and CRP (r = 0.43, p = 0.044). After adjustment for BF leptin emerged as a significant predictor of fibrinogen (beta = 0.47, p = 0.023; R(2) = 0.59, p < 0.001). QUICKI was positively correlated with HDL-cholesterol (r = 0.59, p = 0.010) and negatively with fibrinogen (r = -0.53, p = 0.025), CRP (r = -0.52, p = 0.028) and vWF (r = -0.56, p = 0.013). CONCLUSIONS: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations. 2012-05-28T15:02:24Z 2012-05-28T15:02:24Z 2002 info:eu-repo/semantics/article https://hdl.handle.net/10171/22243 eng http://www.sciencedirect.com/science/article/pii/S000991200200320X info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Obesity Cardiovascular risk Leptin Fibrinogen Insulin sensitivity Gomez-Ambrosi, J. (Javier) Salvador, J. (Javier) Paramo, J.A. (José Antonio) Orbe, J. (Josune) Irala, J. (Jokin) de Diez-Caballero, A. (Alberto) Gil, M.J. (María José) Álvarez-Cienfuegos, J. (Javier) Frühbeck, G. (Gema) Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title | Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title_full | Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title_fullStr | Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title_full_unstemmed | Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title_short | Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| title_sort | involvement of leptin in the association between percentage of body fat and cardiovascular risk factors |
| topic | Obesity Cardiovascular risk Leptin Fibrinogen Insulin sensitivity |
| url | https://hdl.handle.net/10171/22243 |
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