Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis.

Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis.

The antigenic extract Hot Saline from Brucella ovis was microencapsulated by the spray-drying technique with different polyesters (poly-lactide-co-glycolide RG502H [PLGA], and blends with poly-ε-caprolactone [PEC]) in order to obtain microparticles smaller than 5 μm. Microparticles were tested for e...

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Bibliographic Details
Main Authors: Murillo, M. (M.), Gamazo, C. (Carlos), Goñi-Leza, M.M. (María del Mar), Irache, J.M. (Juan Manuel), Blanco-Prieto, M.J. (María José)
Format: info:eu-repo/semantics/article
Language:eng
Published: Elsevier 2012
Subjects:
Brucellosis
Poly-ε-caprolactone
PLGA
Polymeric blend
Spray-drying
Vaccine
Online Access:https://hdl.handle.net/10171/22389

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