Drug delivery systems for potential treatment of intracellular bacterial infections.
Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge. The antibiotic concentration in those specialized niches are often subtherapeutic, for which high doses of antibiotics must often be used. This is n...
| Main Authors: | , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Frontiers in Bioscience
2012
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| Online Access: | https://hdl.handle.net/10171/22391 |
| _version_ | 1793400030652006400 |
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| author | Imbuluzqueta, E. (Edurne) Gamazo, C. (Carlos) Ariza, J. (J.) Blanco-Prieto, M.J. (María José) |
| author_facet | Imbuluzqueta, E. (Edurne) Gamazo, C. (Carlos) Ariza, J. (J.) Blanco-Prieto, M.J. (María José) |
| author_sort | Imbuluzqueta, E. (Edurne) |
| collection | DSpace |
| description | Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge. The antibiotic concentration in those specialized niches are often subtherapeutic, for which high doses of antibiotics must often be used. This is not only costly but may also increase localized or systemic side effects. There is therefore an urgent need for materials and methods to enable clinicians to achieve therapeutically effective intracellular concentration of those antibiotics which show good efficiency in vitro. In this setting, the possible use of drug delivery systems (DDS) loaded with antibiotics that exhibit a high in vitro bactericidal activity deserves to be considered. Entrapping or encapsulating the drug within a delivery system provides a greater control of the pharmacokinetic behavior of the active molecule. This more efficient use of antibiotics may diminish their drawbacks and provide the basis for shortening the current time required by classical treatments. This review will focus on the role of DDS as a potential tool against intracellular bacteria. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22391 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Frontiers in Bioscience |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-223912020-03-23T17:31:40Z Drug delivery systems for potential treatment of intracellular bacterial infections. Imbuluzqueta, E. (Edurne) Gamazo, C. (Carlos) Ariza, J. (J.) Blanco-Prieto, M.J. (María José) Intracellular bacteria Antibiotic treatment Drug delivery system Microparticle Nanoparticle Liposome Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge. The antibiotic concentration in those specialized niches are often subtherapeutic, for which high doses of antibiotics must often be used. This is not only costly but may also increase localized or systemic side effects. There is therefore an urgent need for materials and methods to enable clinicians to achieve therapeutically effective intracellular concentration of those antibiotics which show good efficiency in vitro. In this setting, the possible use of drug delivery systems (DDS) loaded with antibiotics that exhibit a high in vitro bactericidal activity deserves to be considered. Entrapping or encapsulating the drug within a delivery system provides a greater control of the pharmacokinetic behavior of the active molecule. This more efficient use of antibiotics may diminish their drawbacks and provide the basis for shortening the current time required by classical treatments. This review will focus on the role of DDS as a potential tool against intracellular bacteria. 2012-06-01T10:01:08Z 2012-06-01T10:01:08Z 2010-01 info:eu-repo/semantics/article https://hdl.handle.net/10171/22391 eng info:eu-repo/semantics/openAccess application/pdf Frontiers in Bioscience |
| spellingShingle | Intracellular bacteria Antibiotic treatment Drug delivery system Microparticle Nanoparticle Liposome Imbuluzqueta, E. (Edurne) Gamazo, C. (Carlos) Ariza, J. (J.) Blanco-Prieto, M.J. (María José) Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title | Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title_full | Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title_fullStr | Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title_full_unstemmed | Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title_short | Drug delivery systems for potential treatment of intracellular bacterial infections. |
| title_sort | drug delivery systems for potential treatment of intracellular bacterial infections. |
| topic | Intracellular bacteria Antibiotic treatment Drug delivery system Microparticle Nanoparticle Liposome |
| url | https://hdl.handle.net/10171/22391 |
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