A new rapid desensitization protocol for chemotherapy agents
Background: Desensitization has been used for some decades to treat patients with the allergenic drug when an alternative drug with similar effi cacy and safety is not available. We present the results from a series of oncology patients desensitized at our hospital during the last 2 years. Object...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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ESMON Publicidad
2012
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| Online Access: | https://hdl.handle.net/10171/22471 |
| _version_ | 1793399906171355136 |
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| author | Gastaminza, G. (Gabriel) Borbolla, J.M. (J.M.) de la Goikoetxea-Lapresa, M.J. (María José) Escudero, R. (R.) Anton, J. (J.) Espinos, J. (Jaime) Lacasa, C. (Carlos) Fernandez-Benitez, M. (M.) Sanz, M.L. (María Luisa) Ferrer-Cardona, M. (Marta) |
| author_facet | Gastaminza, G. (Gabriel) Borbolla, J.M. (J.M.) de la Goikoetxea-Lapresa, M.J. (María José) Escudero, R. (R.) Anton, J. (J.) Espinos, J. (Jaime) Lacasa, C. (Carlos) Fernandez-Benitez, M. (M.) Sanz, M.L. (María Luisa) Ferrer-Cardona, M. (Marta) |
| author_sort | Gastaminza, G. (Gabriel) |
| collection | DSpace |
| description | Background: Desensitization has been used for some decades to treat patients with the allergenic drug when an alternative drug with
similar effi cacy and safety is not available. We present the results from a series of oncology patients desensitized at our hospital during
the last 2 years.
Objective: To assess the effi cacy of a new desensitization protocol in patients allergic to chemotherapy drugs.
Methods: We performed an observational retrospective study of 11 women (6 breast cancer and 5 ovarian cancer) who underwent our
desensitization protocol. Four patients had immediate reactions to carboplatin, 3 to docetaxel, 3 to paclitaxel, and 1 to both docetaxel
and paclitaxel. Premedication was administered in all cases. A 5-step protocol based on 5 different dilutions of the drugs was used.
Results: We performed 39 desensitization procedures: 14 to carboplatin, 3 to oxaliplatin, 16 to docetaxel, and 6 to paclitaxel. Eight patients
tolerated the full dose in 36 procedures. One patient suffered an anaphylactic reaction to carboplatin that reverted with treatment. One
patient had dyspnea after a paclitaxel cycle. One patient experienced dyspnea due to chronic pulmonary thromboembolism related to
her disease.
Conclusion: Desensitization is a useful procedure in patients who are allergic to their chemotherapy agents. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22471 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | ESMON Publicidad |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-224712024-02-07T11:35:22Z A new rapid desensitization protocol for chemotherapy agents Gastaminza, G. (Gabriel) Borbolla, J.M. (J.M.) de la Goikoetxea-Lapresa, M.J. (María José) Escudero, R. (R.) Anton, J. (J.) Espinos, J. (Jaime) Lacasa, C. (Carlos) Fernandez-Benitez, M. (M.) Sanz, M.L. (María Luisa) Ferrer-Cardona, M. (Marta) Carboplatin Chemotherapy agents Desensitization Background: Desensitization has been used for some decades to treat patients with the allergenic drug when an alternative drug with similar effi cacy and safety is not available. We present the results from a series of oncology patients desensitized at our hospital during the last 2 years. Objective: To assess the effi cacy of a new desensitization protocol in patients allergic to chemotherapy drugs. Methods: We performed an observational retrospective study of 11 women (6 breast cancer and 5 ovarian cancer) who underwent our desensitization protocol. Four patients had immediate reactions to carboplatin, 3 to docetaxel, 3 to paclitaxel, and 1 to both docetaxel and paclitaxel. Premedication was administered in all cases. A 5-step protocol based on 5 different dilutions of the drugs was used. Results: We performed 39 desensitization procedures: 14 to carboplatin, 3 to oxaliplatin, 16 to docetaxel, and 6 to paclitaxel. Eight patients tolerated the full dose in 36 procedures. One patient suffered an anaphylactic reaction to carboplatin that reverted with treatment. One patient had dyspnea after a paclitaxel cycle. One patient experienced dyspnea due to chronic pulmonary thromboembolism related to her disease. Conclusion: Desensitization is a useful procedure in patients who are allergic to their chemotherapy agents. 2012-06-05T10:30:36Z 2012-06-05T10:30:36Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/22471 eng http://www.jiaci.org/issues/vol21issue2/4.pdf info:eu-repo/semantics/openAccess application/pdf ESMON Publicidad |
| spellingShingle | Carboplatin Chemotherapy agents Desensitization Gastaminza, G. (Gabriel) Borbolla, J.M. (J.M.) de la Goikoetxea-Lapresa, M.J. (María José) Escudero, R. (R.) Anton, J. (J.) Espinos, J. (Jaime) Lacasa, C. (Carlos) Fernandez-Benitez, M. (M.) Sanz, M.L. (María Luisa) Ferrer-Cardona, M. (Marta) A new rapid desensitization protocol for chemotherapy agents |
| title | A new rapid desensitization protocol for chemotherapy agents |
| title_full | A new rapid desensitization protocol for chemotherapy agents |
| title_fullStr | A new rapid desensitization protocol for chemotherapy agents |
| title_full_unstemmed | A new rapid desensitization protocol for chemotherapy agents |
| title_short | A new rapid desensitization protocol for chemotherapy agents |
| title_sort | new rapid desensitization protocol for chemotherapy agents |
| topic | Carboplatin Chemotherapy agents Desensitization |
| url | https://hdl.handle.net/10171/22471 |
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