Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics
To assess the correlation between intratumoral vascularization using three-dimensional power Doppler angiography (3D-PDA) and several histological tumor characteristics in a series of patients with endometrial carcinoma. METHODS: Ninety-nine women (mean age, 61.7 (range, 31-84) years) diagnosed...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Wiley-Blackwell
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/22513 |
| _version_ | 1793399922544869376 |
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| author | Galvan, R. (R.) Merce, L. (L.) Jurado, M. (Matías) Minguez, J.A. (J.A.) Lopez-Garcia, G. (Guillermo) Alcazar, J.L. (Juan Luis) |
| author_facet | Galvan, R. (R.) Merce, L. (L.) Jurado, M. (Matías) Minguez, J.A. (J.A.) Lopez-Garcia, G. (Guillermo) Alcazar, J.L. (Juan Luis) |
| author_sort | Galvan, R. (R.) |
| collection | DSpace |
| description | To assess the correlation between intratumoral vascularization using three-dimensional power Doppler angiography (3D-PDA) and several histological tumor characteristics in a series of patients with endometrial carcinoma.
METHODS:
Ninety-nine women (mean age, 61.7 (range, 31-84) years) diagnosed as having endometrial cancer were assessed by transvaginal 3D-PDA before surgical staging. Endometrial volume (EV) and 3D-PDA vascular indices (vascularization index (VI), flow index (FI) and vascularization flow index (VFI)) were calculated using the Virtual Organ Computer-aided AnaLysis (VOCAL) method. All patients were surgically staged. Individual tumor features such as histological type, tumor grade, myometrial infiltration depth, lymph-vascular space involvement, cervical involvement, lymph node metastases and tumor stage were considered for analysis. Multivariate logistic regression (MLR) analysis was used to determine which 3D-PDA parameters were independently associated with each histological characteristic.
RESULTS:
MLR analysis showed that only EV and VI were independently associated with myometrial infiltration (EV: odds ratio (OR), 1.119 (95% CI, 1.025-1.221), P = 0.012; VI: OR, 1.127 (95% CI, 1.063-1.195), P = 0.001) and tumor stage (EV: OR, 1.103 (95% CI, 1.012-1.202), P = 0.025; VI: OR, 1.120 (95% CI, 1.057-1.187), P = 0.001), only VI was independently associated with tumor grade (OR, 1.056 (95% CI, 1.023-1.091), P = 0.001) and only EV was independently associated with lymph node metastases (OR, 1.086 (95% CI, 1.017-1.161), P = 0.001).
CONCLUSION:
3D-PDA analysis of tumor vascularization in endometrial cancer correlates with some prognostic histological characteristics. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22513 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-225132022-06-29T09:28:04Z Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics Galvan, R. (R.) Merce, L. (L.) Jurado, M. (Matías) Minguez, J.A. (J.A.) Lopez-Garcia, G. (Guillermo) Alcazar, J.L. (Juan Luis) Endometrial cancer Histological characteristics Three-dimensional ultrasound To assess the correlation between intratumoral vascularization using three-dimensional power Doppler angiography (3D-PDA) and several histological tumor characteristics in a series of patients with endometrial carcinoma. METHODS: Ninety-nine women (mean age, 61.7 (range, 31-84) years) diagnosed as having endometrial cancer were assessed by transvaginal 3D-PDA before surgical staging. Endometrial volume (EV) and 3D-PDA vascular indices (vascularization index (VI), flow index (FI) and vascularization flow index (VFI)) were calculated using the Virtual Organ Computer-aided AnaLysis (VOCAL) method. All patients were surgically staged. Individual tumor features such as histological type, tumor grade, myometrial infiltration depth, lymph-vascular space involvement, cervical involvement, lymph node metastases and tumor stage were considered for analysis. Multivariate logistic regression (MLR) analysis was used to determine which 3D-PDA parameters were independently associated with each histological characteristic. RESULTS: MLR analysis showed that only EV and VI were independently associated with myometrial infiltration (EV: odds ratio (OR), 1.119 (95% CI, 1.025-1.221), P = 0.012; VI: OR, 1.127 (95% CI, 1.063-1.195), P = 0.001) and tumor stage (EV: OR, 1.103 (95% CI, 1.012-1.202), P = 0.025; VI: OR, 1.120 (95% CI, 1.057-1.187), P = 0.001), only VI was independently associated with tumor grade (OR, 1.056 (95% CI, 1.023-1.091), P = 0.001) and only EV was independently associated with lymph node metastases (OR, 1.086 (95% CI, 1.017-1.161), P = 0.001). CONCLUSION: 3D-PDA analysis of tumor vascularization in endometrial cancer correlates with some prognostic histological characteristics. 2012-06-08T18:08:11Z 2012-06-08T18:08:11Z 2010 info:eu-repo/semantics/article https://hdl.handle.net/10171/22513 eng http://onlinelibrary.wiley.com/doi/10.1002/uog.7633/pdf info:eu-repo/semantics/openAccess application/pdf Wiley-Blackwell |
| spellingShingle | Endometrial cancer Histological characteristics Three-dimensional ultrasound Galvan, R. (R.) Merce, L. (L.) Jurado, M. (Matías) Minguez, J.A. (J.A.) Lopez-Garcia, G. (Guillermo) Alcazar, J.L. (Juan Luis) Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title | Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title_full | Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title_fullStr | Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title_full_unstemmed | Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title_short | Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics |
| title_sort | three-dimensional power doppler angiography in endometrial cancer: correlation with tumor characteristics |
| topic | Endometrial cancer Histological characteristics Three-dimensional ultrasound |
| url | https://hdl.handle.net/10171/22513 |
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