Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications
To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS: In the reliability study, two independent examiners obt...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Association for Research in Vision and Ophthalmology
2012
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| Online Access: | https://hdl.handle.net/10171/22536 |
| _version_ | 1793400099273965568 |
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| author | Moreno-Montañes, J. (Javier) Maldonado, M.J. (Miguel J.) Garcia, N. (Noelia) Mendiluce, L. (Loreto) Garcia-Gomez, P.J. (Pío J.) Segui-Gomez, M. (María) |
| author_facet | Moreno-Montañes, J. (Javier) Maldonado, M.J. (Miguel J.) Garcia, N. (Noelia) Mendiluce, L. (Loreto) Garcia-Gomez, P.J. (Pío J.) Segui-Gomez, M. (María) |
| author_sort | Moreno-Montañes, J. (Javier) |
| collection | DSpace |
| description | To assess the reproducibility of the ocular response analyzer (ORA) in
nonoperated eyes and the impact of corneal biomechanical properties on
intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS:
In the reliability study, two independent examiners obtained repeated ORA
measurements in 30 eyes. In the clinical study, the examiners analyzed ORA and
IOP-Goldmann values from 220 normal and 42 glaucomatous eyes. In both studies,
Goldmann-correlated IOP measurement (IOP-ORAg), corneal-compensated IOP
(IOP-ORAc), corneal hysteresis (CH), and corneal resistance factor (CRF) were
evaluated. IOP differences of 3 mm Hg or greater between the IOP-ORAc and
IOP-ORAg were considered outcome significant. RESULTS: Intraexaminer intraclass
correlation coefficients and interexaminer concordance correlation coefficients
ranged from 0.78 to 0.93 and from 0.81 to 0.93, respectively, for all parameters.
CH reproducibility was highest, and the IOP-ORAg readings were lowest. The median
IOP was 16 mm Hg with the Goldmann tonometer, 14.5 mm Hg with IOP-ORAg (P <
0.001), and 15.7 mm Hg with IOP-ORAc (P < 0.001). Outcome-significant results
were found in 77 eyes (29.38%). The IOP-ORAc, CH, and CRF were correlated with
age (r = 0.22, P = 0.001; r = -0.23, P = 0.001; r = -0.14, P = 0.02,
respectively), but not the IOP-ORAg or IOP-Goldmann. CONCLUSIONS: The ORA
provides reproducible corneal biomechanical and IOP measurements in nonoperated
eyes. Considering the effect of ORA, corneal biomechanical metrics produces an
outcome-significant IOP adjustment in at least one quarter of glaucomatous and
normal eyes undergoing noncontact tonometry. Corneal viscoelasticity (CH) and
resistance (CRF) appear to decrease minimally with increasing age in healthy
adults. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22536 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-225362020-03-03T20:15:14Z Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications Moreno-Montañes, J. (Javier) Maldonado, M.J. (Miguel J.) Garcia, N. (Noelia) Mendiluce, L. (Loreto) Garcia-Gomez, P.J. (Pío J.) Segui-Gomez, M. (María) Glaucoma, open-Angle/diagnosis Intraocular pressure/physiology Elastic tissue/physiology To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS: In the reliability study, two independent examiners obtained repeated ORA measurements in 30 eyes. In the clinical study, the examiners analyzed ORA and IOP-Goldmann values from 220 normal and 42 glaucomatous eyes. In both studies, Goldmann-correlated IOP measurement (IOP-ORAg), corneal-compensated IOP (IOP-ORAc), corneal hysteresis (CH), and corneal resistance factor (CRF) were evaluated. IOP differences of 3 mm Hg or greater between the IOP-ORAc and IOP-ORAg were considered outcome significant. RESULTS: Intraexaminer intraclass correlation coefficients and interexaminer concordance correlation coefficients ranged from 0.78 to 0.93 and from 0.81 to 0.93, respectively, for all parameters. CH reproducibility was highest, and the IOP-ORAg readings were lowest. The median IOP was 16 mm Hg with the Goldmann tonometer, 14.5 mm Hg with IOP-ORAg (P < 0.001), and 15.7 mm Hg with IOP-ORAc (P < 0.001). Outcome-significant results were found in 77 eyes (29.38%). The IOP-ORAc, CH, and CRF were correlated with age (r = 0.22, P = 0.001; r = -0.23, P = 0.001; r = -0.14, P = 0.02, respectively), but not the IOP-ORAg or IOP-Goldmann. CONCLUSIONS: The ORA provides reproducible corneal biomechanical and IOP measurements in nonoperated eyes. Considering the effect of ORA, corneal biomechanical metrics produces an outcome-significant IOP adjustment in at least one quarter of glaucomatous and normal eyes undergoing noncontact tonometry. Corneal viscoelasticity (CH) and resistance (CRF) appear to decrease minimally with increasing age in healthy adults. 2012-06-11T16:51:11Z 2012-06-11T16:51:11Z 2008 info:eu-repo/semantics/article https://hdl.handle.net/10171/22536 eng http://www.iovs.org/content/49/3/968.full.pdf+html info:eu-repo/semantics/openAccess application/pdf Association for Research in Vision and Ophthalmology |
| spellingShingle | Glaucoma, open-Angle/diagnosis Intraocular pressure/physiology Elastic tissue/physiology Moreno-Montañes, J. (Javier) Maldonado, M.J. (Miguel J.) Garcia, N. (Noelia) Mendiluce, L. (Loreto) Garcia-Gomez, P.J. (Pío J.) Segui-Gomez, M. (María) Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title | Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title_full | Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title_fullStr | Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title_full_unstemmed | Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title_short | Reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| title_sort | reproducibility and clinical relevance of the ocular response analyzer in nonoperated eyes: corneal biomechanical and tonometric implications |
| topic | Glaucoma, open-Angle/diagnosis Intraocular pressure/physiology Elastic tissue/physiology |
| url | https://hdl.handle.net/10171/22536 |
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