Farmacología de los azoles
Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake. All of them have high tissue distribution with low plasma concentrations...
| Main Authors: | , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | spa |
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Elsevier España
2012
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| Online Access: | https://hdl.handle.net/10171/22724 |
| _version_ | 1793400198839402496 |
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| author | Azanza, J.R. (José Ramón) Garcia-Quetglas, E. (Emilio) Sadaba, B. (Belén) |
| author_facet | Azanza, J.R. (José Ramón) Garcia-Quetglas, E. (Emilio) Sadaba, B. (Belén) |
| author_sort | Azanza, J.R. (José Ramón) |
| collection | DSpace |
| description | Azole antifungals have different pharmacokinetic characteristics: complete oral
absorption for Voriconazole, and to a lesser extent for fluconazole.
The absorption of posaconazole and itraconazole increases with food intake.
All of them have high tissue distribution with low plasma concentrations,
especially low in the case of posaconazole and itraconazole. Posaconazole
and itraconazole have high plasmatic protein binding and consequently both
have a very low free fraction. Elimination of azole antifungals is through a
metabolic pathway with CYP450 isoenzymes, and has a non linear
pharmacokinetics with a high risk of interation with other drugs since azoles
have the ability of CYP450 isoenzymes inhibition. Possibly the parameter that
defines more precisely their efficacy is AUIC with an optimum value near 20,
although cut-off values must be defined since some azoles may have difficulty
to reach this value. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22724 |
| institution | Universidad de Navarra |
| language | spa |
| publishDate | 2012 |
| publisher | Elsevier España |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-227242020-03-03T22:22:38Z Farmacología de los azoles Azanza, J.R. (José Ramón) Garcia-Quetglas, E. (Emilio) Sadaba, B. (Belén) Pharmacology Posaconazole Itraconazole Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake. All of them have high tissue distribution with low plasma concentrations, especially low in the case of posaconazole and itraconazole. Posaconazole and itraconazole have high plasmatic protein binding and consequently both have a very low free fraction. Elimination of azole antifungals is through a metabolic pathway with CYP450 isoenzymes, and has a non linear pharmacokinetics with a high risk of interation with other drugs since azoles have the ability of CYP450 isoenzymes inhibition. Possibly the parameter that defines more precisely their efficacy is AUIC with an optimum value near 20, although cut-off values must be defined since some azoles may have difficulty to reach this value. 2012-06-27T12:03:33Z 2012-06-27T12:03:33Z 2007 info:eu-repo/semantics/article https://hdl.handle.net/10171/22724 spa http://www.reviberoammicol.com/2007-24/223227.pdf info:eu-repo/semantics/openAccess application/pdf Elsevier España |
| spellingShingle | Pharmacology Posaconazole Itraconazole Azanza, J.R. (José Ramón) Garcia-Quetglas, E. (Emilio) Sadaba, B. (Belén) Farmacología de los azoles |
| title | Farmacología de los azoles |
| title_full | Farmacología de los azoles |
| title_fullStr | Farmacología de los azoles |
| title_full_unstemmed | Farmacología de los azoles |
| title_short | Farmacología de los azoles |
| title_sort | farmacología de los azoles |
| topic | Pharmacology Posaconazole Itraconazole |
| url | https://hdl.handle.net/10171/22724 |
| work_keys_str_mv | AT azanzajrjoseramon farmacologiadelosazoles AT garciaquetglaseemilio farmacologiadelosazoles AT sadababbelen farmacologiadelosazoles |