Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort.
The use of aspirin and non-aspirin analgesics has been associated with changes in blood pressure. The aim of this study was to investigate prospectively the association between the regular use of aspirin and non-aspirin analgesics and the incidence of hypertension. METHODS: The SUN project is an...
| Príomhchruthaitheoirí: | , , , , , |
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| Formáid: | info:eu-repo/semantics/article |
| Teanga: | eng |
| Foilsithe / Cruthaithe: |
Elsevier España
2012
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| Ábhair: | |
| Rochtain ar líne: | https://hdl.handle.net/10171/22848 |
| _version_ | 1793400169113321472 |
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| author | Beunza, J.J. (Juan José) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Nuñez-Cordoba, J.M. (Jorge M.) Toledo, E. (Estefanía) Alonso, A. (Alvaro) |
| author_facet | Beunza, J.J. (Juan José) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Nuñez-Cordoba, J.M. (Jorge M.) Toledo, E. (Estefanía) Alonso, A. (Alvaro) |
| author_sort | Beunza, J.J. (Juan José) |
| collection | DSpace |
| description | The use of aspirin and non-aspirin analgesics has been associated with changes in blood pressure. The aim of this study was to investigate prospectively the association between the regular use of aspirin and non-aspirin analgesics and the incidence of hypertension.
METHODS:
The SUN project is an ongoing, continuously expanding, prospective cohort of Spanish university graduates initially free of hypertension, cardiovascular disease, diabetes and cancer; 9986 (mean age 36 years) were recruited during 1999-2005 and followed up for a mean of 51 months. Regular aspirin and non-aspirin analgesic use and the presence of other risk factors for hypertension were assessed by questionnaire at baseline, and the incidence of hypertension was assessed using biennial follow-up questionnaires.
RESULTS:
In total, 543 new cases of hypertension were identified during follow-up. Regular aspirin use (i.e. 2 or more days/week) was associated with a higher risk of hypertension (hazard ratio=1.45; 95% confidence interval, 1.02-2.04) after adjustment for various confounding factors. Regular use of non-aspirin analgesic drugs was also associated with a higher risk of hypertension (hazard ratio=1.69; 95% confidence interval, 1.28-2.23).
CONCLUSIONS:
The regular use of aspirin and non-aspirin analgesics were both associated with an increased risk of developing hypertension, independently of other risk factors. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-22848 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Elsevier España |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-228482022-06-29T09:41:38Z Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. Beunza, J.J. (Juan José) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Nuñez-Cordoba, J.M. (Jorge M.) Toledo, E. (Estefanía) Alonso, A. (Alvaro) Anti-Inflammatory agents, Non-steroidal/adverse effects Aspirin/adverse effects Hypertension/chemically induced/epidemiology The use of aspirin and non-aspirin analgesics has been associated with changes in blood pressure. The aim of this study was to investigate prospectively the association between the regular use of aspirin and non-aspirin analgesics and the incidence of hypertension. METHODS: The SUN project is an ongoing, continuously expanding, prospective cohort of Spanish university graduates initially free of hypertension, cardiovascular disease, diabetes and cancer; 9986 (mean age 36 years) were recruited during 1999-2005 and followed up for a mean of 51 months. Regular aspirin and non-aspirin analgesic use and the presence of other risk factors for hypertension were assessed by questionnaire at baseline, and the incidence of hypertension was assessed using biennial follow-up questionnaires. RESULTS: In total, 543 new cases of hypertension were identified during follow-up. Regular aspirin use (i.e. 2 or more days/week) was associated with a higher risk of hypertension (hazard ratio=1.45; 95% confidence interval, 1.02-2.04) after adjustment for various confounding factors. Regular use of non-aspirin analgesic drugs was also associated with a higher risk of hypertension (hazard ratio=1.69; 95% confidence interval, 1.28-2.23). CONCLUSIONS: The regular use of aspirin and non-aspirin analgesics were both associated with an increased risk of developing hypertension, independently of other risk factors. 2012-07-06T08:22:30Z 2012-07-06T08:22:30Z 2010 info:eu-repo/semantics/article https://hdl.handle.net/10171/22848 eng info:eu-repo/semantics/openAccess application/pdf Elsevier España |
| spellingShingle | Anti-Inflammatory agents, Non-steroidal/adverse effects Aspirin/adverse effects Hypertension/chemically induced/epidemiology Beunza, J.J. (Juan José) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Nuñez-Cordoba, J.M. (Jorge M.) Toledo, E. (Estefanía) Alonso, A. (Alvaro) Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title | Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title_full | Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title_fullStr | Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title_full_unstemmed | Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title_short | Aspirin, non-aspirin analgesics and the risk of hypertension in the SUN cohort. |
| title_sort | aspirin, non-aspirin analgesics and the risk of hypertension in the sun cohort. |
| topic | Anti-Inflammatory agents, Non-steroidal/adverse effects Aspirin/adverse effects Hypertension/chemically induced/epidemiology |
| url | https://hdl.handle.net/10171/22848 |
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