Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

4-phenylbutyrate (PBA) is a small molecule that restores cognitive deficits in animal models of Alzheimer's disease (AD). Although the molecular basis of the cognitive benefits of PBA remains unknown, a multi-modal/multi-target mechanism has been proposed. Putative targets of this drug are diff...

書目詳細資料
Main Authors:	Cuadrado-Tejedor, M. (Mar), Garcia-Osta, A. (Ana), Ricobaraza, A. (Ana), Oyarzabal, J. (Julen), Franco, R. (Rafael)
格式:	info:eu-repo/semantics/article
語言:	eng
出版:	Bentham Science Publ LTD 2012
主題:	Alzheimer's disease chaperone histone deacetylase phenylbutyrate amyloid and Tau amyloid Tau 4-phenylbutyrate multi-target mechanism enzymes therapeutic effects
在線閱讀:	https://hdl.handle.net/10171/23299

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