Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies
Results obtained in this study suggest that in human brucellosis there is an antibody response against platelet-activating factor (PAF) and phosphatidylcholine (PC). The specificity of the antiphospholipid response was determined by inhibition assays. The PAF molecule was able t...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Society for General Microbiology
2012
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| Online Access: | https://hdl.handle.net/10171/23358 |
| _version_ | 1793400075116871680 |
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| author | Casao, M.A. (María Ángeles) Diaz, R. (Ramón) Orduña, A. (Antonio) Gamazo, C. (Carlos) |
| author_facet | Casao, M.A. (María Ángeles) Diaz, R. (Ramón) Orduña, A. (Antonio) Gamazo, C. (Carlos) |
| author_sort | Casao, M.A. (María Ángeles) |
| collection | DSpace |
| description | Results obtained in this study suggest that in human brucellosis there is an
antibody response against platelet-activating factor (PAF) and
phosphatidylcholine (PC). The specificity of the antiphospholipid response was
determined by inhibition assays. The PAF molecule was able to inhibit the anti-PC
activity of the brucellosis-control serum. This inhibition capacity of PAF was
similar to that of the phosphorylcholine (PYC) group. These results suggest that
the inhibition activity could be attributed to the PYC group present in both PAF
and PC molecules. Consequently, these findings support an immunodominant role of
PYC in the antiphospholipid response of brucellosis. Furthermore, sera from
patients infected with Brucella organisms were able to cause platelet
aggregation, as were brucella phospholipids, suggesting a possible role of the
antiphospholipid antibodies and phospholipids in the inflammatory response in
brucellosis. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23358 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Society for General Microbiology |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-233582020-03-03T22:19:32Z Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies Casao, M.A. (María Ángeles) Diaz, R. (Ramón) Orduña, A. (Antonio) Gamazo, C. (Carlos) Antibodies, Bacterial/blood/immunology Antibody Specificity Brucellosis/immunology/physiopathology Results obtained in this study suggest that in human brucellosis there is an antibody response against platelet-activating factor (PAF) and phosphatidylcholine (PC). The specificity of the antiphospholipid response was determined by inhibition assays. The PAF molecule was able to inhibit the anti-PC activity of the brucellosis-control serum. This inhibition capacity of PAF was similar to that of the phosphorylcholine (PYC) group. These results suggest that the inhibition activity could be attributed to the PYC group present in both PAF and PC molecules. Consequently, these findings support an immunodominant role of PYC in the antiphospholipid response of brucellosis. Furthermore, sera from patients infected with Brucella organisms were able to cause platelet aggregation, as were brucella phospholipids, suggesting a possible role of the antiphospholipid antibodies and phospholipids in the inflammatory response in brucellosis. 2012-10-15T10:23:50Z 2012-10-15T10:23:50Z 2001 info:eu-repo/semantics/article https://hdl.handle.net/10171/23358 eng http://jmm.sgmjournals.org/content/50/11/965.long info:eu-repo/semantics/openAccess application/pdf Society for General Microbiology |
| spellingShingle | Antibodies, Bacterial/blood/immunology Antibody Specificity Brucellosis/immunology/physiopathology Casao, M.A. (María Ángeles) Diaz, R. (Ramón) Orduña, A. (Antonio) Gamazo, C. (Carlos) Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title_full | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title_fullStr | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title_full_unstemmed | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title_short | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| title_sort | promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies |
| topic | Antibodies, Bacterial/blood/immunology Antibody Specificity Brucellosis/immunology/physiopathology |
| url | https://hdl.handle.net/10171/23358 |
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