Review: mitochondrial defects in breast cancer
Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Mitochondrial DNA has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear D...
| Main Authors: | , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Libertas Academica
2012
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/23383 |
| _version_ | 1793400391317061632 |
|---|---|
| author | Salgado, J. (Josefa) Honorato-Cía, B. (Beatriz) Garcia-Foncillas, J. (Jesús) |
| author_facet | Salgado, J. (Josefa) Honorato-Cía, B. (Beatriz) Garcia-Foncillas, J. (Jesús) |
| author_sort | Salgado, J. (Josefa) |
| collection | DSpace |
| description | Mitochondria play important roles in cellular energy metabolism, free radical
generation, and apoptosis. Mitochondrial DNA has been proposed to be involved in
carcinogenesis because of its high susceptibility to mutations and limited repair
mechanisms in comparison to nuclear DNA. Breast cancer is the most frequent
cancer type among women in the world and, although exhaustive research has been
done on nuclear DNA changes, several studies describe a variety of mitochondrial
DNA alterations present in breast cancer. In this review article, we to provide a
summary of the mitochondrial genomic alterations reported in breast cancer and
their functional consequences. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23383 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Libertas Academica |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-233832023-09-21T09:36:54Z Review: mitochondrial defects in breast cancer Salgado, J. (Josefa) Honorato-Cía, B. (Beatriz) Garcia-Foncillas, J. (Jesús) Breast cancer Mitochondrial Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Mitochondrial DNA has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. Breast cancer is the most frequent cancer type among women in the world and, although exhaustive research has been done on nuclear DNA changes, several studies describe a variety of mitochondrial DNA alterations present in breast cancer. In this review article, we to provide a summary of the mitochondrial genomic alterations reported in breast cancer and their functional consequences. 2012-10-15T14:25:36Z 2012-10-15T14:25:36Z 2008 info:eu-repo/semantics/article https://hdl.handle.net/10171/23383 eng http://www.la-press.com/mitochondrial-defects-in-breast-cancer-article-a681 info:eu-repo/semantics/openAccess application/pdf Libertas Academica |
| spellingShingle | Breast cancer Mitochondrial Salgado, J. (Josefa) Honorato-Cía, B. (Beatriz) Garcia-Foncillas, J. (Jesús) Review: mitochondrial defects in breast cancer |
| title | Review: mitochondrial defects in breast cancer |
| title_full | Review: mitochondrial defects in breast cancer |
| title_fullStr | Review: mitochondrial defects in breast cancer |
| title_full_unstemmed | Review: mitochondrial defects in breast cancer |
| title_short | Review: mitochondrial defects in breast cancer |
| title_sort | review: mitochondrial defects in breast cancer |
| topic | Breast cancer Mitochondrial |
| url | https://hdl.handle.net/10171/23383 |
| work_keys_str_mv | AT salgadojjosefa reviewmitochondrialdefectsinbreastcancer AT honoratociabbeatriz reviewmitochondrialdefectsinbreastcancer AT garciafoncillasjjesus reviewmitochondrialdefectsinbreastcancer |