Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.
The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy- 3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked t...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
MDPI
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/23596 |
| Summary: | The unexpected substitution of fluorine atoms and phenoxy groups attached to
quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy-
3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction.
The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced
by a methoxy group when dissolved in an ammonia saturated solution of methanol was
clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives
became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous
ammonia. |
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