Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.
The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy- 3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked t...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
MDPI
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/23596 |
| _version_ | 1793400188612640768 |
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| author | Vicente, E. (Esther) Raquel Burguete, A. (Asunción) Solano, B. (Beatriz) Ancizu, S. (Saioa) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) |
| author_facet | Vicente, E. (Esther) Raquel Burguete, A. (Asunción) Solano, B. (Beatriz) Ancizu, S. (Saioa) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) |
| author_sort | Vicente, E. (Esther) |
| collection | DSpace |
| description | The unexpected substitution of fluorine atoms and phenoxy groups attached to
quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy-
3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction.
The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced
by a methoxy group when dissolved in an ammonia saturated solution of methanol was
clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives
became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous
ammonia. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23596 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-235962022-11-28T11:33:54Z Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. Vicente, E. (Esther) Raquel Burguete, A. (Asunción) Solano, B. (Beatriz) Ancizu, S. (Saioa) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) Quinoxaline N-oxides Beirut reaction Gaseous ammonia The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy- 3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced by a methoxy group when dissolved in an ammonia saturated solution of methanol was clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous ammonia. 2012-10-31T16:26:06Z 2012-10-31T16:26:06Z 2008 info:eu-repo/semantics/article https://hdl.handle.net/10171/23596 eng http://www.mdpi.com/journal/molecules info:eu-repo/semantics/openAccess application/pdf MDPI |
| spellingShingle | Quinoxaline N-oxides Beirut reaction Gaseous ammonia Vicente, E. (Esther) Raquel Burguete, A. (Asunción) Solano, B. (Beatriz) Ancizu, S. (Saioa) Pérez-Silanes, S. (Silvia) Aldana, I. (Ignacio) Monge, A. (Antonio) Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title | Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title_full | Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title_fullStr | Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title_full_unstemmed | Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title_short | Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. |
| title_sort | substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-n-oxide derivatives. |
| topic | Quinoxaline N-oxides Beirut reaction Gaseous ammonia |
| url | https://hdl.handle.net/10171/23596 |
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