Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1...

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Bibliographic Details
Main Authors: Ancizu, S. (Saioa), Moreno-de-Viguri, E. (Elsa), Torres, E. (Enrique), Burguete, A. (Asunción), Pérez-Silanes, S. (Silvia), Benitez, D. (Diego), Raquel, Solano, B. (Beatriz), Marin, A. (Adoración), Aldana, I. (Ignacio), Cerecetto, H. (Hugo), Gonzalez, M. (Mercedes), Monge, A. (Antonio)
Format: info:eu-repo/semantics/article
Language:eng
Published: MDPI 2012
Subjects:
Quinoxaline
Neglected diseases
Mycobacterium tuberculosis
Trypanosoma cruz
Online Access:https://hdl.handle.net/10171/23599
Description
Summary:Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order as the anti-chagasic drug, nifurtimox.

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