Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Ancizu, S. (Saioa), Moreno-de-Viguri, E. (Elsa), Torres, E. (Enrique), Burguete, A. (Asunción), Pérez-Silanes, S. (Silvia), Benitez, D. (Diego), Raquel, Solano, B. (Beatriz), Marin, A. (Adoración), Aldana, I. (Ignacio), Cerecetto, H. (Hugo), Gonzalez, M. (Mercedes), Monge, A. (Antonio)
Format:	info:eu-repo/semantics/article
Sprog:	eng
Udgivet:	MDPI 2012
Fag:	Quinoxaline Neglected diseases Mycobacterium tuberculosis Trypanosoma cruz
Online adgang:	https://hdl.handle.net/10171/23599

Lignende værker

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis
af: Vicente, E. (Esther), et al.
Udgivet: (2013)

The Rose Bengal Test in human brucellosis: a neglected test for the diagnosis of a neglected disease
af: Diaz, R. (Ramón), et al.
Udgivet: (2013)

Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
af: Henriquez-Figuereo, A. (Andreina), et al.
Udgivet: (2023)

Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives.
af: Monge, A. (Antonio), et al.
Udgivet: (2014)

Raising the political profile of the neglected zoonotic diseases: three complementary European commission-funded projects to streamline research, build capacity and advocate for control
af: Okello, A.L. (Anna L.), et al.
Udgivet: (2015)

New quinoxaline 1,4-di-N-oxide derivatives: Trypanosomaticidal activities and enzyme docking simulation
af: Estevez, Y. (Yannick), et al.
Udgivet: (2014)

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti- Mycobacterium tuberculosis agents.
af: Monge, A. (Antonio), et al.
Udgivet: (2014)

Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis
af: Vicente, E. (Esther), et al.
Udgivet: (2011)

Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs
af: Rubio-Hernández, M. (Mercedes), et al.
Udgivet: (2022)

Análisis comparativo del perfil de susceptibilidad de mycobacterium tuberculosis frente a fármacos de primera línea de tratamiento en pacientes del Hospital Vicente Corral Moscoso en el período 2021 - 2022
af: Torres Largo, Tatiana Elizabeth, et al.
Udgivet: (2023)

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents
af: Pérez-Silanes, S. (Silvia), et al.
Udgivet: (2014)

Riesgo y prevención de la transmisión de enfermedades infecciosas en odontología
af: Araujo, Marcelo W. B.Andreana, Sebastiano

Selected non-heterocyclic polycyclic aromatic hydrocarbonsPolycyclic aromatic hydrocarbons, selected non-heterocyclic

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity
af: Pérez-Silanes, S. (Silvia), et al.
Udgivet: (2016)

Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
af: Barea, C. (Carlos), et al.
Udgivet: (2012)

An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine
af: Rivera, G. (Gildardo), et al.
Udgivet: (2013)

Dificultades en la adherencia al tratamiento de la tuberculosis
af: García Jiménez, Laura
Udgivet: (2019)

Cyclic voltammetric study of some anti-Chagas-active 1,4-dioxidoquinoxalin-2-yl ketone derivatives
af: Crawford, P.W. (Philip W.), et al.
Udgivet: (2014)

Tipificación de cepas de Mycobacterium bovis. Revisión

Quimioterapia anti-Trypanosoma cruzi: Acción de nuevos compuestos frente a diferentes dianas terapéuticas
af: López Becerra, David
Udgivet: (2022)

Unexpected reduction of ethyl 3-phenylquinoxaline-2- carboxylate 1,4-di-N-oxide derivatives by amines.
af: Lima, L.M. (Lidia M.), et al.
Udgivet: (2012)

Métodos directo y por concentración para la identificación del mycobacterium tuberculosis en esputo hospital Neumológico-Cuenca 1989
af: Jaramillo O., J. Fabricio, et al.
Udgivet: (2014)

Tuberculosis hepática como causa de fiebre de origen desconocido

Tuberculosis hepática como causa de fiebre de origen desconocido

Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives
af: Burguete, A. (Asunción), et al.
Udgivet: (2015)

Colectomía total en megacolon chagásico Hospital Vicente Corral Moscoso, Cuenca
af: Villa F., EdgarNaula S., SaraMedina Rodríguez, Elizabeth

Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases /
Udgivet: (2010)

Desarrollo de un inmuno-ensayo enzimático (ELISA) para el diagnóstico de paratuberculosis en bovinos

Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease
af: Beltrán-Hortelano, I. (Iván), et al.
Udgivet: (2022)

Prevalencia de anticuerpos para Mycobacterium avium subespecie paratuberculosis en hatos lecheros de la sierra sur del Ecuador. Azuay - Cañar
af: Cárdenas Morocho, Ana Alexandra, et al.
Udgivet: (2017)

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
af: Pizarro-Cerda, J. (Javier), et al.
Udgivet: (2013)

New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
af: Barea, C. (Carlos), et al.
Udgivet: (2013)

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide
af: Raquel, et al.
Udgivet: (2013)

Effective method for a graphene oxide with impressive selectivity in carboxyl groups
af: Rodríguez Pastor, Iluminada, et al.
Udgivet: (2022)

El Eslabón perdido 2
af: Maitland A., Edey

Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity.
af: Alguacil Alarcón, Andrés, et al.
Udgivet: (2024)

New quinoxaline and indole derivatives as MT1 and MT2 receptor agonists
af: Ancizu, S. (Saioa), et al.
Udgivet: (2014)

Reseñas 29/2 (1996)
af: Ortiz-de-Landázuri, C. (Carlos), et al.
Udgivet: (2012)

Masters 2
af: Glass, Philip

Communicate 2