Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against er...

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Bibliographic Details
Main Authors: Barea, C. (Carlos), Pabon, A. (Adriana), Galiano, S. (Silvia), Pérez-Silanes, S. (Silvia), Gonzalez, G. (Germán), Deyssard, C. (Chloe), Monge, A. (Antonio), Deharo, E. (Eric), Aldana, I. (Ignacio)
Format: info:eu-repo/semantics/article
Language:eng
Published: MDPI 2012
Subjects:
Quinxaline
Piperazine
Plasmodium
Leishmania
VERO
Online Access:https://hdl.handle.net/10171/23601
Description
Summary:Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.

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