Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against er...
| Main Authors: | , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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MDPI
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/23601 |
| _version_ | 1793400189750345728 |
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| author | Barea, C. (Carlos) Pabon, A. (Adriana) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Gonzalez, G. (Germán) Deyssard, C. (Chloe) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) |
| author_facet | Barea, C. (Carlos) Pabon, A. (Adriana) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Gonzalez, G. (Germán) Deyssard, C. (Chloe) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) |
| author_sort | Barea, C. (Carlos) |
| collection | DSpace |
| description | Malaria and leishmaniasis are two of the World’s most important tropical
parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline
1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro
antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium
falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells
(normal monkey kidney cells) was also assessed. None of the tested compounds was
efficient against Plasmodium, but two of them showed good activity against Leishmania.
Toxicity on VERO was correlated with leishmanicidal properties. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23601 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-236012020-03-04T02:47:32Z Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. Barea, C. (Carlos) Pabon, A. (Adriana) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Gonzalez, G. (Germán) Deyssard, C. (Chloe) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) Quinxaline Piperazine Plasmodium Leishmania VERO Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties. 2012-10-31T17:42:13Z 2012-10-31T17:42:13Z 2012 info:eu-repo/semantics/article https://hdl.handle.net/10171/23601 eng http://www.mdpi.com/journal/molecules info:eu-repo/semantics/openAccess application/pdf MDPI |
| spellingShingle | Quinxaline Piperazine Plasmodium Leishmania VERO Barea, C. (Carlos) Pabon, A. (Adriana) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Gonzalez, G. (Germán) Deyssard, C. (Chloe) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title | Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title_full | Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title_fullStr | Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title_full_unstemmed | Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title_short | Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| title_sort | antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. |
| topic | Quinxaline Piperazine Plasmodium Leishmania VERO |
| url | https://hdl.handle.net/10171/23601 |
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