Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma
To compare the ability of transvaginal sonography and serum CA 125 levels to predict myometrial invasion in patients with endometrial carcinoma. DESIGN AND METHODS: Prospective study in 50 consecutive patients (mean age 60 years, SD 10.5, range 29-77 years) diagnosed as having e...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Wiley-Blackwell
2012
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| Online Access: | https://hdl.handle.net/10171/23667 |
| _version_ | 1793399927163846656 |
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| author | Alcazar, J.L. (Juan Luis) Jurado, M. (Matías) Lopez-Garcia, G. (Guillermo) |
| author_facet | Alcazar, J.L. (Juan Luis) Jurado, M. (Matías) Lopez-Garcia, G. (Guillermo) |
| author_sort | Alcazar, J.L. (Juan Luis) |
| collection | DSpace |
| description | To compare the ability of transvaginal sonography and serum CA 125
levels to predict myometrial invasion in patients with endometrial carcinoma.
DESIGN AND METHODS: Prospective study in 50 consecutive patients (mean age 60
years, SD 10.5, range 29-77 years) diagnosed as having endometrial cancer and
scheduled for surgical staging. All patients were evaluated by transvaginal
ultrasonography. Endometrial thickness was measured in all cases and myometrial
invasion was estimated as < 50% or > or = 50%. Serum CA 125 level was determined
in each patient. A cut-off level of > or = 35 IU/ml was considered to predict
myometrial invasion of > or = 50%. All patients underwent surgical staging, and
definitive histopathological findings regarding myometrial invasion were used as
the 'gold standard'. Sensitivity, specificity and positive predictive value (PPV)
and negative predictive value (NPV) were calculated for transvaginal
ultrasonography and CA 125 and compared. RESULTS: On histopathological analysis,
myometrial invasion was found to be < 50% in 35 (70%) cases and > or = 50% in 15
cases (30%). Mean endometrial thickness in patients with superficial invasion was
significantly lower than in those with deep invasion (13.4 mm (95% CI 11.2-15.7)
vs. 18.7 mm (95% CI 15.0-22.3), respectively; p = 0.014). Median CA 125 was
significantly higher in patients with deep invasion than in those with
superficial invasion (30 IU/ml, interquartile range (IQR) 46.0 vs. 16.9 IU/ml,
IQR 13.9, respectively; p = 0.002). The sensitivity, specificity, PPV and NPV for
transvaginal ultrasonography were 86.7% (95% CI 59.5-98.3), 94.3% (95% CI
80.8-99.3), 86.7% (95% CI 59.5-98.3) and 94.3% (95% CI 80.8-99.3), respectively.
The sensitivity, specificity, PPV and NPV for CA 125 were 40% (95% CI 16.3-67.7),
91.4% (95% CI 76.9-98.2), 66.7% (95% CI 29.9-92.5) and 78% (95% CI 63.4-89.5),
respectively. The sensitivity of transvaginal ultrasonography was significantly
higher than that of CA 125 (p = 0.008). No differences were found in terms of
specificity, PPV or NPV. CONCLUSION: Our results indicate that transvaginal
ultrasonography is more sensitive than CA 125 in predicting myometrial invasion
in endometrial cancer. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23667 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-236672022-06-29T09:28:04Z Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma Alcazar, J.L. (Juan Luis) Jurado, M. (Matías) Lopez-Garcia, G. (Guillermo) Endometrial Neoplasms/diagnosis/pathology/surgery/*ultrasonography Endometrium/pathology MH - Female Myometrium/pathology To compare the ability of transvaginal sonography and serum CA 125 levels to predict myometrial invasion in patients with endometrial carcinoma. DESIGN AND METHODS: Prospective study in 50 consecutive patients (mean age 60 years, SD 10.5, range 29-77 years) diagnosed as having endometrial cancer and scheduled for surgical staging. All patients were evaluated by transvaginal ultrasonography. Endometrial thickness was measured in all cases and myometrial invasion was estimated as < 50% or > or = 50%. Serum CA 125 level was determined in each patient. A cut-off level of > or = 35 IU/ml was considered to predict myometrial invasion of > or = 50%. All patients underwent surgical staging, and definitive histopathological findings regarding myometrial invasion were used as the 'gold standard'. Sensitivity, specificity and positive predictive value (PPV) and negative predictive value (NPV) were calculated for transvaginal ultrasonography and CA 125 and compared. RESULTS: On histopathological analysis, myometrial invasion was found to be < 50% in 35 (70%) cases and > or = 50% in 15 cases (30%). Mean endometrial thickness in patients with superficial invasion was significantly lower than in those with deep invasion (13.4 mm (95% CI 11.2-15.7) vs. 18.7 mm (95% CI 15.0-22.3), respectively; p = 0.014). Median CA 125 was significantly higher in patients with deep invasion than in those with superficial invasion (30 IU/ml, interquartile range (IQR) 46.0 vs. 16.9 IU/ml, IQR 13.9, respectively; p = 0.002). The sensitivity, specificity, PPV and NPV for transvaginal ultrasonography were 86.7% (95% CI 59.5-98.3), 94.3% (95% CI 80.8-99.3), 86.7% (95% CI 59.5-98.3) and 94.3% (95% CI 80.8-99.3), respectively. The sensitivity, specificity, PPV and NPV for CA 125 were 40% (95% CI 16.3-67.7), 91.4% (95% CI 76.9-98.2), 66.7% (95% CI 29.9-92.5) and 78% (95% CI 63.4-89.5), respectively. The sensitivity of transvaginal ultrasonography was significantly higher than that of CA 125 (p = 0.008). No differences were found in terms of specificity, PPV or NPV. CONCLUSION: Our results indicate that transvaginal ultrasonography is more sensitive than CA 125 in predicting myometrial invasion in endometrial cancer. 2012-11-08T11:51:48Z 2012-11-08T11:51:48Z 1999 info:eu-repo/semantics/article https://hdl.handle.net/10171/23667 eng http://onlinelibrary.wiley.com/doi/10.1046/j.1469-0705.1999.14030210.x/pdf info:eu-repo/semantics/openAccess application/pdf Wiley-Blackwell |
| spellingShingle | Endometrial Neoplasms/diagnosis/pathology/surgery/*ultrasonography Endometrium/pathology MH - Female Myometrium/pathology Alcazar, J.L. (Juan Luis) Jurado, M. (Matías) Lopez-Garcia, G. (Guillermo) Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title | Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title_full | Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title_fullStr | Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title_full_unstemmed | Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title_short | Comparative study of transvaginal ultrasonography and CA 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| title_sort | comparative study of transvaginal ultrasonography and ca 125 in the preoperative evaluation of myometrial invasion in endometrial carcinoma |
| topic | Endometrial Neoplasms/diagnosis/pathology/surgery/*ultrasonography Endometrium/pathology MH - Female Myometrium/pathology |
| url | https://hdl.handle.net/10171/23667 |
| work_keys_str_mv | AT alcazarjljuanluis comparativestudyoftransvaginalultrasonographyandca125inthepreoperativeevaluationofmyometrialinvasioninendometrialcarcinoma AT juradommatias comparativestudyoftransvaginalultrasonographyandca125inthepreoperativeevaluationofmyometrialinvasioninendometrialcarcinoma AT lopezgarciagguillermo comparativestudyoftransvaginalultrasonographyandca125inthepreoperativeevaluationofmyometrialinvasioninendometrialcarcinoma |