New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colomb...
| Main Authors: | , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/23742 |
| _version_ | 1793400190456037376 |
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| author | Barea, C. (Carlos) Pabon, A. (Adriana) Castillo, D. (Denis) Zimic, M. (Mirko) Quiliano, M. (Miguel) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) |
| author_facet | Barea, C. (Carlos) Pabon, A. (Adriana) Castillo, D. (Denis) Zimic, M. (Mirko) Quiliano, M. (Miguel) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) |
| author_sort | Barea, C. (Carlos) |
| collection | DSpace |
| description | Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-23742 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-237422020-03-04T02:12:47Z New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities Barea, C. (Carlos) Pabon, A. (Adriana) Castillo, D. (Denis) Zimic, M. (Mirko) Quiliano, M. (Miguel) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) Quinoxaline N-oxides Malaria Leishmaniasis Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found 2012-11-20T18:30:20Z 2012-11-20T18:30:20Z 2011 info:eu-repo/semantics/article https://hdl.handle.net/10171/23742 eng info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Quinoxaline N-oxides Malaria Leishmaniasis Barea, C. (Carlos) Pabon, A. (Adriana) Castillo, D. (Denis) Zimic, M. (Mirko) Quiliano, M. (Miguel) Galiano, S. (Silvia) Pérez-Silanes, S. (Silvia) Monge, A. (Antonio) Deharo, E. (Eric) Aldana, I. (Ignacio) New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title_full | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title_fullStr | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title_full_unstemmed | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title_short | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| title_sort | new salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-n-oxide with antileishmanial and antimalarial activities |
| topic | Quinoxaline N-oxides Malaria Leishmaniasis |
| url | https://hdl.handle.net/10171/23742 |
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