Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas
Antimicrobials with specific activity against Gram-positive cocci (glycopeptides, oxazolidinones and streptogramins) have pharmacokinetic differences that are important to know. Linezolid and teicoplanin can be administered extravascularly due to their good bioavailability, all...
| Main Authors: | , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | spa |
| Published: |
Sociedad Española de Quimioterapia
2013
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/27543 |
| _version_ | 1793400200591572992 |
|---|---|
| author | Garcia-Quetglas, E. (Emilio) Azanza, J.R. (José Ramón) Sadaba, B. (Belén) Gil-Aldea, I. (I.) |
| author_facet | Garcia-Quetglas, E. (Emilio) Azanza, J.R. (José Ramón) Sadaba, B. (Belén) Gil-Aldea, I. (I.) |
| author_sort | Garcia-Quetglas, E. (Emilio) |
| collection | DSpace |
| description | Antimicrobials with specific activity against Gram-positive cocci (glycopeptides,
oxazolidinones and streptogramins) have pharmacokinetic differences that are
important to know. Linezolid and teicoplanin can be administered extravascularly
due to their good bioavailability, allowing their use as sequential therapy in
patients requiring prolonged treatment. All of these antimicrobials have an
adequate distribution in extracellular tissues, even teicoplanin, due to the
balance between the fraction that is bound and unbound to plasma proteins and its
long terminal half-life. As the elimination of glycopeptides is almost
exclusively renal, it is necessary to perform a posology adjustment in patients
with renal failure. Quinupristin/dalfopristin and linezolid are metabolized by
the liver, but CYP450 is only involved in streptogramin elimination |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-27543 |
| institution | Universidad de Navarra |
| language | spa |
| publishDate | 2013 |
| publisher | Sociedad Española de Quimioterapia |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-275432020-03-03T19:43:38Z Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas Garcia-Quetglas, E. (Emilio) Azanza, J.R. (José Ramón) Sadaba, B. (Belén) Gil-Aldea, I. (I.) Anti-Bacterial Agents/blood/pharmacology/therapeutic use Dose-Response Relationship, Drug Gram-Positive Bacterial Infections/drug therapy Antimicrobials with specific activity against Gram-positive cocci (glycopeptides, oxazolidinones and streptogramins) have pharmacokinetic differences that are important to know. Linezolid and teicoplanin can be administered extravascularly due to their good bioavailability, allowing their use as sequential therapy in patients requiring prolonged treatment. All of these antimicrobials have an adequate distribution in extracellular tissues, even teicoplanin, due to the balance between the fraction that is bound and unbound to plasma proteins and its long terminal half-life. As the elimination of glycopeptides is almost exclusively renal, it is necessary to perform a posology adjustment in patients with renal failure. Quinupristin/dalfopristin and linezolid are metabolized by the liver, but CYP450 is only involved in streptogramin elimination 2013-01-02T09:17:31Z 2013-01-02T09:17:31Z 2003 info:eu-repo/semantics/article https://hdl.handle.net/10171/27543 spa http://www.seq.es/seq/0214-3429/16/3/277.pdf info:eu-repo/semantics/openAccess application/pdf Sociedad Española de Quimioterapia |
| spellingShingle | Anti-Bacterial Agents/blood/pharmacology/therapeutic use Dose-Response Relationship, Drug Gram-Positive Bacterial Infections/drug therapy Garcia-Quetglas, E. (Emilio) Azanza, J.R. (José Ramón) Sadaba, B. (Belén) Gil-Aldea, I. (I.) Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title | Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title_full | Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title_fullStr | Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title_full_unstemmed | Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title_short | Farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| title_sort | farmacología de antimicrobianos utilizados en el tratamiento de las infecciones graves por bacterias grampositivas |
| topic | Anti-Bacterial Agents/blood/pharmacology/therapeutic use Dose-Response Relationship, Drug Gram-Positive Bacterial Infections/drug therapy |
| url | https://hdl.handle.net/10171/27543 |
| work_keys_str_mv | AT garciaquetglaseemilio farmacologiadeantimicrobianosutilizadoseneltratamientodelasinfeccionesgravesporbacteriasgrampositivas AT azanzajrjoseramon farmacologiadeantimicrobianosutilizadoseneltratamientodelasinfeccionesgravesporbacteriasgrampositivas AT sadababbelen farmacologiadeantimicrobianosutilizadoseneltratamientodelasinfeccionesgravesporbacteriasgrampositivas AT gilaldeaii farmacologiadeantimicrobianosutilizadoseneltratamientodelasinfeccionesgravesporbacteriasgrampositivas |