Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives
The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in orde...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng spa |
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Universidade de São Paulo
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/29500 |
| _version_ | 1793400191848546304 |
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| author | Zarranz, B. (Belén) Jaso, A. (Andrés) Lima, L.M. (Lidia M.) Aldana, I. (Ignacio) Monge, A. (Antonio) Maurel, S. (Séverine) Sauvain, M. (Michel) |
| author_facet | Zarranz, B. (Belén) Jaso, A. (Andrés) Lima, L.M. (Lidia M.) Aldana, I. (Ignacio) Monge, A. (Antonio) Maurel, S. (Séverine) Sauvain, M. (Michel) |
| author_sort | Zarranz, B. (Belén) |
| collection | DSpace |
| description | The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-29500 |
| institution | Universidad de Navarra |
| language | eng spa |
| publishDate | 2013 |
| publisher | Universidade de São Paulo |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-295002020-03-03T21:41:56Z Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives Zarranz, B. (Belén) Jaso, A. (Andrés) Lima, L.M. (Lidia M.) Aldana, I. (Ignacio) Monge, A. (Antonio) Maurel, S. (Séverine) Sauvain, M. (Michel) Quinoxaline Antimalarial Chloroquine MCF7 The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity. 2013-07-17T07:34:42Z 2013-07-17T07:34:42Z 2006 info:eu-repo/semantics/article https://hdl.handle.net/10171/29500 eng spa info:eu-repo/semantics/openAccess application/pdf Universidade de São Paulo |
| spellingShingle | Quinoxaline Antimalarial Chloroquine MCF7 Zarranz, B. (Belén) Jaso, A. (Andrés) Lima, L.M. (Lidia M.) Aldana, I. (Ignacio) Monge, A. (Antonio) Maurel, S. (Séverine) Sauvain, M. (Michel) Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title | Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title_full | Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title_fullStr | Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title_full_unstemmed | Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title_short | Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives |
| title_sort | antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-n-oxide derivatives |
| topic | Quinoxaline Antimalarial Chloroquine MCF7 |
| url | https://hdl.handle.net/10171/29500 |
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