New antagonist agents of Neuropeptide Y receptors

In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as ant...

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ग्रंथसूची विवरण
मुख्य लेखकों: Aldana, I. (Ignacio), Rivero, I. (Isabel), Rivero, A. (Argimiro), Huenchuñir, P. (Patricio), Frigola, C. (Carmen), Alonso, M.L. (María Luisa), Monge, A. (Antonio)
स्वरूप: info:eu-repo/semantics/article
भाषा:eng
प्रकाशित: Sociedade Brasileira de Química 2013
विषय:
ऑनलाइन पहुंच:https://hdl.handle.net/10171/29641
विवरण
सारांश:In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists mill be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.