Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project
Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Informa Healthcare
2013
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| Online Access: | https://hdl.handle.net/10171/34618 |
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| author | Galbete, C. (Cecilia) Contreras, R. (Rafael) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Guillen-Grima, F. (Francisco) Marti-del-Moral, A. (Amelia) |
| author_facet | Galbete, C. (Cecilia) Contreras, R. (Rafael) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Guillen-Grima, F. (Francisco) Marti-del-Moral, A. (Amelia) |
| author_sort | Galbete, C. (Cecilia) |
| collection | DSpace |
| description | Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN (“Seguimiento Universidad de Navarra”) Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT- subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METs- h/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-34618 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2013 |
| publisher | Informa Healthcare |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-346182024-01-24T08:58:36Z Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project Galbete, C. (Cecilia) Contreras, R. (Rafael) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Guillen-Grima, F. (Francisco) Marti-del-Moral, A. (Amelia) CLOCK rs1801260 Cross-sectional study Obesity risk Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN (“Seguimiento Universidad de Navarra”) Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT- subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METs- h/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project. 2013-12-09T08:37:22Z 2013-12-09T08:37:22Z 2012 info:eu-repo/semantics/article https://hdl.handle.net/10171/34618 eng info:eu-repo/semantics/openAccess application/pdf Informa Healthcare |
| spellingShingle | CLOCK rs1801260 Cross-sectional study Obesity risk Galbete, C. (Cecilia) Contreras, R. (Rafael) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Guillen-Grima, F. (Francisco) Marti-del-Moral, A. (Amelia) Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title_full | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title_fullStr | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title_full_unstemmed | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title_short | Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project |
| title_sort | physical activity and sex modulate obesity risk linked to 3111t/c gene variant of the clock gene in an elderly population: the sun project |
| topic | CLOCK rs1801260 Cross-sectional study Obesity risk |
| url | https://hdl.handle.net/10171/34618 |
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