Growth factor loaded-microparticles as a tool for cardiac repair
The clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by...
| Main Authors: | , , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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Servicio de Publicaciones Universidad de Navarra
2014
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| Online Access: | https://hdl.handle.net/10171/34921 |
| _version_ | 1793400587659771904 |
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| author | Rocha, F. (Fabio) Pelacho, B. (Beatriz) Blanco-Prieto, M.J. (María José) |
| author_facet | Rocha, F. (Fabio) Pelacho, B. (Beatriz) Blanco-Prieto, M.J. (María José) |
| author_sort | Rocha, F. (Fabio) |
| collection | DSpace |
| description | The clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by using a polymeric delivery system could protect the growth factors from degradation and stimulate cardiac repair. To test this, the following specific objectives were proposed:
1. Design, development and physico-chemical characterization of PLGA microparticles intended for intramyocardial administration. In vivo compatibility assessment of the developed microparticles with the cardiac tissue.
2. Development of VEGF165 loaded PLGA microparticles, in vitro characterization and assessment of the potential benefit of the VEGF165-microparticles in an acute rat myocardial ischemia– reperfusion model.
3. Development of FGF-1 and NRG-1 into PLGA microparticles, in vitro characterization and evaluation of the therapeutic potential of FGF-1 and/or NRG-1 cytokines delivered from PLGA microparticles in a rat myocardial infarction model. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-34921 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Servicio de Publicaciones Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-349212020-03-23T17:31:40Z Growth factor loaded-microparticles as a tool for cardiac repair Rocha, F. (Fabio) Pelacho, B. (Beatriz) Blanco-Prieto, M.J. (María José) Materias Investigacion::Farmacia The clinical trials performed in patients with myocardial infarction and based on the intravascular injection of growth factors have failed, owing, among other reasons, to protein instability after injection. The hypothesis of this research is that a local controlled release of the growth factors by using a polymeric delivery system could protect the growth factors from degradation and stimulate cardiac repair. To test this, the following specific objectives were proposed: 1. Design, development and physico-chemical characterization of PLGA microparticles intended for intramyocardial administration. In vivo compatibility assessment of the developed microparticles with the cardiac tissue. 2. Development of VEGF165 loaded PLGA microparticles, in vitro characterization and assessment of the potential benefit of the VEGF165-microparticles in an acute rat myocardial ischemia– reperfusion model. 3. Development of FGF-1 and NRG-1 into PLGA microparticles, in vitro characterization and evaluation of the therapeutic potential of FGF-1 and/or NRG-1 cytokines delivered from PLGA microparticles in a rat myocardial infarction model. 2014-01-22T16:37:08Z 2014-01-22T16:37:08Z 2014 2011-12-15 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/34921 eng info:eu-repo/semantics/openAccess application/pdf Servicio de Publicaciones Universidad de Navarra |
| spellingShingle | Materias Investigacion::Farmacia Rocha, F. (Fabio) Pelacho, B. (Beatriz) Blanco-Prieto, M.J. (María José) Growth factor loaded-microparticles as a tool for cardiac repair |
| title | Growth factor loaded-microparticles as a tool for cardiac repair |
| title_full | Growth factor loaded-microparticles as a tool for cardiac repair |
| title_fullStr | Growth factor loaded-microparticles as a tool for cardiac repair |
| title_full_unstemmed | Growth factor loaded-microparticles as a tool for cardiac repair |
| title_short | Growth factor loaded-microparticles as a tool for cardiac repair |
| title_sort | growth factor loaded-microparticles as a tool for cardiac repair |
| topic | Materias Investigacion::Farmacia |
| url | https://hdl.handle.net/10171/34921 |
| work_keys_str_mv | AT rochaffabio growthfactorloadedmicroparticlesasatoolforcardiacrepair AT pelachobbeatriz growthfactorloadedmicroparticlesasatoolforcardiacrepair AT blancoprietomjmariajose growthfactorloadedmicroparticlesasatoolforcardiacrepair |