Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man
Controversy still exists regarding the role of cholinergic pathways in the regulation of the hypothalamic-pituitary-adrenal axis in man. We studied the effects of the administration of placebo, pyridostigmine (PD); 120 mg, orally), and the combination of PD and pirenzepine (PZP; 100 mg, orally) on A...
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| Format: | info:eu-repo/semantics/article |
| Jezik: | eng |
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The endocrine society
2014
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| Teme: | |
| Online dostop: | https://hdl.handle.net/10171/35489 |
| _version_ | 1793400104742289408 |
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| author | Llorente, I. (Ignacio) Lizcano, F. (Fernando) Alvarez, R. (Rosa) Diez-Goñi, N. (Nieves) Sopena, M. (Marcos) Gil, M.J. (María José) Salvador, J. (Javier) |
| author_facet | Llorente, I. (Ignacio) Lizcano, F. (Fernando) Alvarez, R. (Rosa) Diez-Goñi, N. (Nieves) Sopena, M. (Marcos) Gil, M.J. (María José) Salvador, J. (Javier) |
| author_sort | Llorente, I. (Ignacio) |
| collection | DSpace |
| description | Controversy still exists regarding the role of cholinergic pathways in the regulation of the hypothalamic-pituitary-adrenal axis in man. We studied the effects of the administration of placebo, pyridostigmine (PD); 120 mg, orally), and the combination of PD and pirenzepine (PZP; 100 mg, orally) on ACTH, cortisol, and GH secretion at 0730 and 2230 h in seven normal males. PD induced a clear decrease in ACTH levels at both times of the day compared to treatment with placebo, producing higher suppression in the nocturnal period (34.4 +/- 5.8% vs. 21.8 +/- 10.7%). The combination PD and PZP prevented the inhibitory action of PD on ACTH secretion in the morning, but not in the evening, when ACTH values showed a decrease similar to that seen after giving PD alone (38.1 +/- 5.6% vs. 34.4 +/- 5.8%, respectively). Cortisol values declined only when the association PD plus PZP was given in the evening. GH levels had a significant increase after PD administration in the morning (4.1 +/- 1.2 ng/mL) and in the evening (10.2 +/- 1.6 ng/mL), confirming that cholinergic stimulation was taking place, whereas the addition of PZP to PD induced a significant attenuation of these responses. It is concluded that cholinergic pathways have a inhibitory role in ACTH secretion in man. M1 muscarinic receptors seem to be involved in the diurnal inhibition of PD, whereas our observations are consistent with the mediation of another type of cholinergic receptors as an explanation for the nocturnal effect of PD on ACTH secretion. PD did not alter the circadian variation in the hypothalamic-pituitary-adrenal axis, whereas the association of PD and PZP increased the differences between diurnal and nocturnal ACTH values, suggesting a modulatory effect of the cholinergic system on the circadian rhythm of ACTH secretion. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-35489 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | The endocrine society |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-354892020-03-03T11:08:55Z Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man Llorente, I. (Ignacio) Lizcano, F. (Fernando) Alvarez, R. (Rosa) Diez-Goñi, N. (Nieves) Sopena, M. (Marcos) Gil, M.J. (María José) Salvador, J. (Javier) Circadian Rhythm Hypothalamo-Hypophyseal Parasympathetic Nervous Pituitary-Adrenal System Adrenocorticotropic Hormone Cholinesterase Controversy still exists regarding the role of cholinergic pathways in the regulation of the hypothalamic-pituitary-adrenal axis in man. We studied the effects of the administration of placebo, pyridostigmine (PD); 120 mg, orally), and the combination of PD and pirenzepine (PZP; 100 mg, orally) on ACTH, cortisol, and GH secretion at 0730 and 2230 h in seven normal males. PD induced a clear decrease in ACTH levels at both times of the day compared to treatment with placebo, producing higher suppression in the nocturnal period (34.4 +/- 5.8% vs. 21.8 +/- 10.7%). The combination PD and PZP prevented the inhibitory action of PD on ACTH secretion in the morning, but not in the evening, when ACTH values showed a decrease similar to that seen after giving PD alone (38.1 +/- 5.6% vs. 34.4 +/- 5.8%, respectively). Cortisol values declined only when the association PD plus PZP was given in the evening. GH levels had a significant increase after PD administration in the morning (4.1 +/- 1.2 ng/mL) and in the evening (10.2 +/- 1.6 ng/mL), confirming that cholinergic stimulation was taking place, whereas the addition of PZP to PD induced a significant attenuation of these responses. It is concluded that cholinergic pathways have a inhibitory role in ACTH secretion in man. M1 muscarinic receptors seem to be involved in the diurnal inhibition of PD, whereas our observations are consistent with the mediation of another type of cholinergic receptors as an explanation for the nocturnal effect of PD on ACTH secretion. PD did not alter the circadian variation in the hypothalamic-pituitary-adrenal axis, whereas the association of PD and PZP increased the differences between diurnal and nocturnal ACTH values, suggesting a modulatory effect of the cholinergic system on the circadian rhythm of ACTH secretion. 2014-03-12T15:12:32Z 2014-03-12T15:12:32Z 1996 info:eu-repo/semantics/article https://hdl.handle.net/10171/35489 eng info:eu-repo/semantics/openAccess info:eu-repo/semantics/openAccess application/pdf The endocrine society |
| spellingShingle | Circadian Rhythm Hypothalamo-Hypophyseal Parasympathetic Nervous Pituitary-Adrenal System Adrenocorticotropic Hormone Cholinesterase Llorente, I. (Ignacio) Lizcano, F. (Fernando) Alvarez, R. (Rosa) Diez-Goñi, N. (Nieves) Sopena, M. (Marcos) Gil, M.J. (María José) Salvador, J. (Javier) Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title | Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title_full | Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title_fullStr | Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title_full_unstemmed | Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title_short | Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| title_sort | cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man |
| topic | Circadian Rhythm Hypothalamo-Hypophyseal Parasympathetic Nervous Pituitary-Adrenal System Adrenocorticotropic Hormone Cholinesterase |
| url | https://hdl.handle.net/10171/35489 |
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