Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives.
As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/35793 |
| _version_ | 1793400193696137216 |
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| author | Monge, A. (Antonio) Aldana, I. (Ignacio) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Ancizu, S. (Saioa) Moreno-de-Viguri, E. (Elsa) |
| author_facet | Monge, A. (Antonio) Aldana, I. (Ignacio) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Ancizu, S. (Saioa) Moreno-de-Viguri, E. (Elsa) |
| author_sort | Monge, A. (Antonio) |
| collection | DSpace |
| description | As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H37Rv. Active compounds were also screened to assess toxicity to a VERO cell line. Results indicate that compounds with a methyl moiety substituted in position 3 and unsubstituted benzyl substituted on the carboxamide group provide an efficient approach for further development of anti-tuberculosis agents. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-35793 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-357932020-03-04T00:25:17Z Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. Monge, A. (Antonio) Aldana, I. (Ignacio) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Ancizu, S. (Saioa) Moreno-de-Viguri, E. (Elsa) Mycobacterium tuberculosis Anti-tuberculosis agents N-oxides Quinoxaline As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H37Rv. Active compounds were also screened to assess toxicity to a VERO cell line. Results indicate that compounds with a methyl moiety substituted in position 3 and unsubstituted benzyl substituted on the carboxamide group provide an efficient approach for further development of anti-tuberculosis agents. 2014-04-12T17:38:49Z 2014-04-12T17:38:49Z 2010-07-03 info:eu-repo/semantics/article https://hdl.handle.net/10171/35793 eng PIUNA project from University of Navarra. Tuberculosis Antimicrobial Acquisition & Coordinating Facility (TAACF) info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Mycobacterium tuberculosis Anti-tuberculosis agents N-oxides Quinoxaline Monge, A. (Antonio) Aldana, I. (Ignacio) Torres, E. (Enrique) Pérez-Silanes, S. (Silvia) Ancizu, S. (Saioa) Moreno-de-Viguri, E. (Elsa) Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title_full | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title_fullStr | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title_full_unstemmed | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title_short | Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives. |
| title_sort | synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-n-oxide derivatives. |
| topic | Mycobacterium tuberculosis Anti-tuberculosis agents N-oxides Quinoxaline |
| url | https://hdl.handle.net/10171/35793 |
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