A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
BACKGROUND: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncerta...
| Main Authors: | , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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BioMed Central
2014
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| Online Access: | https://hdl.handle.net/10171/35845 |
| _version_ | 1793400126476124160 |
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| author | Perez-Cornago, A. (Aurora) Iglesia, R. (Rocío) de la Lopez-Legarrea, P. (Patricia) Abete, I. (Itziar) Navas-Carretero, S. (Santiago) Lacunza, C.I. (Clara I.) Lahortiga, F. (Francisca) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Zulet, M.A. (María Ángeles) |
| author_facet | Perez-Cornago, A. (Aurora) Iglesia, R. (Rocío) de la Lopez-Legarrea, P. (Patricia) Abete, I. (Itziar) Navas-Carretero, S. (Santiago) Lacunza, C.I. (Clara I.) Lahortiga, F. (Francisca) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Zulet, M.A. (María Ángeles) |
| author_sort | Perez-Cornago, A. (Aurora) |
| collection | DSpace |
| description | BACKGROUND:
Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors.
METHODS:
Sixty subjects (Age:50 +/- 1 y; BMI:36.1 +/- 0.6 kg/m2) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated.
RESULTS:
Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 +/- 0.8 vs RESMENA group -3.2 +/- 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95%CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95%CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95%CI = 1.8-6.8), CRP (-42.8%; 95%CI = 0.6-3.0) and insulin (-37.7%; 95%CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95%CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95%CI = 0.04-0.28) and CRP (B = 0.24, 95%CI = 0.01-0.46) concentrations.
CONCLUSIONS:
The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-35845 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-358452024-01-26T11:45:48Z A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study Perez-Cornago, A. (Aurora) Iglesia, R. (Rocío) de la Lopez-Legarrea, P. (Patricia) Abete, I. (Itziar) Navas-Carretero, S. (Santiago) Lacunza, C.I. (Clara I.) Lahortiga, F. (Francisca) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Zulet, M.A. (María Ángeles) Metabolic syndrome Depression Inflammation Leptin Hypocaloric diet Adiposity BACKGROUND: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors. METHODS: Sixty subjects (Age:50 +/- 1 y; BMI:36.1 +/- 0.6 kg/m2) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated. RESULTS: Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 +/- 0.8 vs RESMENA group -3.2 +/- 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95%CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95%CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95%CI = 1.8-6.8), CRP (-42.8%; 95%CI = 0.6-3.0) and insulin (-37.7%; 95%CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95%CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95%CI = 0.04-0.28) and CRP (B = 0.24, 95%CI = 0.01-0.46) concentrations. CONCLUSIONS: The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS. 2014-05-12T11:35:44Z 2014-05-12T11:35:44Z 2014 info:eu-repo/semantics/article https://hdl.handle.net/10171/35845 eng info:eu-repo/semantics/openAccess application/pdf BioMed Central |
| spellingShingle | Metabolic syndrome Depression Inflammation Leptin Hypocaloric diet Adiposity Perez-Cornago, A. (Aurora) Iglesia, R. (Rocío) de la Lopez-Legarrea, P. (Patricia) Abete, I. (Itziar) Navas-Carretero, S. (Santiago) Lacunza, C.I. (Clara I.) Lahortiga, F. (Francisca) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Zulet, M.A. (María Ángeles) A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title | A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title_full | A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title_fullStr | A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title_full_unstemmed | A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title_short | A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| title_sort | decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study |
| topic | Metabolic syndrome Depression Inflammation Leptin Hypocaloric diet Adiposity |
| url | https://hdl.handle.net/10171/35845 |
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