Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant reci...

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Bibliographic Details
Main Authors: Pozo, J.L. (José Luis) del, Fernandez-Ros, N. (Nerea), Saez, E. (Elena), Herrero, J.I. (José Ignacio), Yuste, J.R. (José Ramón), Banales, J.M. (Jesús M.)
Format: info:eu-repo/semantics/article
Language:eng
Published: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY5874227 - 4229 2014
Online Access:https://hdl.handle.net/10171/36096
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Summary:Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.