Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism
Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant reci...
| Main Authors: | , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY5874227 - 4229
2014
|
| Online Access: | https://hdl.handle.net/10171/36096 |
| _version_ | 1793399989189214208 |
|---|---|
| author | Pozo, J.L. (José Luis) del Fernandez-Ros, N. (Nerea) Saez, E. (Elena) Herrero, J.I. (José Ignacio) Yuste, J.R. (José Ramón) Banales, J.M. (Jesús M.) |
| author_facet | Pozo, J.L. (José Luis) del Fernandez-Ros, N. (Nerea) Saez, E. (Elena) Herrero, J.I. (José Ignacio) Yuste, J.R. (José Ramón) Banales, J.M. (Jesús M.) |
| author_sort | Pozo, J.L. (José Luis) del |
| collection | DSpace |
| description | Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in
patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term
linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-36096 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY5874227 - 4229 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-360962020-03-03T11:09:20Z Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism Pozo, J.L. (José Luis) del Fernandez-Ros, N. (Nerea) Saez, E. (Elena) Herrero, J.I. (José Ignacio) Yuste, J.R. (José Ramón) Banales, J.M. (Jesús M.) Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism. 2014-06-20T09:10:39Z 2014-06-20T09:10:39Z 2014 info:eu-repo/semantics/article info:eu-repo/semantics/article https://hdl.handle.net/10171/36096 eng info:eu-repo/semantics/openAccess application/pdf ANTIMICROBIAL AGENTS AND CHEMOTHERAPY5874227 - 4229 |
| spellingShingle | Pozo, J.L. (José Luis) del Fernandez-Ros, N. (Nerea) Saez, E. (Elena) Herrero, J.I. (José Ignacio) Yuste, J.R. (José Ramón) Banales, J.M. (Jesús M.) Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title | Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title_full | Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title_fullStr | Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title_full_unstemmed | Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title_short | Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism |
| title_sort | linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial dna a2706g polymorphism |
| url | https://hdl.handle.net/10171/36096 |
| work_keys_str_mv | AT pozojljoseluisdel linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism AT fernandezrosnnerea linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism AT saezeelena linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism AT herrerojijoseignacio linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism AT yustejrjoseramon linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism AT banalesjmjesusm linezolidinducedlacticacidosisintwolivertransplantpatientswiththemitochondrialdnaa2706gpolymorphism |