Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial
Background: Telomeres are nucleoprotein structures that protect the ends of eukaryote chromosomes. Shorter telomere length (TL) is associated with some age-related human disorders, but its relationship with obesity or adiposity parameters remains unclear. Objective: The aim of this study was to asse...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Nature Publishing Group
2014
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| Online Access: | https://hdl.handle.net/10171/37017 |
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| author | Garcia-Calzon, S. (Sonia) Gea, A. (Alfredo) Razquin, C. (Cristina) Corella, D. (Dolores) Lamuela-Raventos, R.M. (Rosa Maria) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Zalba, G. (Guillermo) Marti-del-Moral, A. (Amelia) |
| author_facet | Garcia-Calzon, S. (Sonia) Gea, A. (Alfredo) Razquin, C. (Cristina) Corella, D. (Dolores) Lamuela-Raventos, R.M. (Rosa Maria) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Zalba, G. (Guillermo) Marti-del-Moral, A. (Amelia) |
| author_sort | Garcia-Calzon, S. (Sonia) |
| collection | DSpace |
| description | Background: Telomeres are nucleoprotein structures that protect the ends of eukaryote chromosomes. Shorter telomere length (TL) is associated with some age-related human disorders, but its relationship with obesity or adiposity parameters remains unclear. Objective: The aim of this study was to assess the relationship between TL and changes in adiposity indices after a 5-year nutritional intervention.
Design and subjects: TL was measured by quantitative real-time PCR in 521 subjects (55-80 years, 55% women). Participants were randomly selected from the PREDIMED-NAVARRA centre after they completed a 5-year intervention programme. Anthropometric parameters were directly measured by trained personnel at baseline and on a yearly basis thereafter. TL at baseline and changes in TL after 5-year intervention were assessed.
Results: Higher baseline TL significantly predicted a greater decrease in body weight (B= -1.09 kg, 95%CI: -2.01 to -0.16), BMI (B= -0.47 kg/m2, 95%CI: -0.83 to -0.11), waist circumference (B= -1.15 cm, 95%CI: -2.28 to -0.01), and waist to height ratio (B= -0.008, 95%CI: -0.010 to -0.001) in multiple-adjusted models. In addition, changes in TL during the 5-year intervention were inversely associated with changes in the four anthropometric variables. The reduction in adiposity indices during the intervention, associated with increasing TL, was even higher among subjects with the longest telomeres at baseline. Logistic regression analysis showed that the risk of remaining obese after 5 years was lower in those participants who initially had the longest telomeres and increased their TL after intervention (OR=0.27, 95%CI: 0.03 to 2.03).
Conclusions: Our research suggests that TL is inversely associated with changes in obesity parameters. The assessment of TL can provide further insights for biological pathways leading to adiposity. We show for the first time an improvement of obesity indices when an increase in TL is observed after a 5-year Mediterranean diet intervention. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-37017 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-370172024-01-24T08:58:36Z Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial Garcia-Calzon, S. (Sonia) Gea, A. (Alfredo) Razquin, C. (Cristina) Corella, D. (Dolores) Lamuela-Raventos, R.M. (Rosa Maria) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Zalba, G. (Guillermo) Marti-del-Moral, A. (Amelia) Telomere length Adiposity Aging Nutritional intervention Background: Telomeres are nucleoprotein structures that protect the ends of eukaryote chromosomes. Shorter telomere length (TL) is associated with some age-related human disorders, but its relationship with obesity or adiposity parameters remains unclear. Objective: The aim of this study was to assess the relationship between TL and changes in adiposity indices after a 5-year nutritional intervention. Design and subjects: TL was measured by quantitative real-time PCR in 521 subjects (55-80 years, 55% women). Participants were randomly selected from the PREDIMED-NAVARRA centre after they completed a 5-year intervention programme. Anthropometric parameters were directly measured by trained personnel at baseline and on a yearly basis thereafter. TL at baseline and changes in TL after 5-year intervention were assessed. Results: Higher baseline TL significantly predicted a greater decrease in body weight (B= -1.09 kg, 95%CI: -2.01 to -0.16), BMI (B= -0.47 kg/m2, 95%CI: -0.83 to -0.11), waist circumference (B= -1.15 cm, 95%CI: -2.28 to -0.01), and waist to height ratio (B= -0.008, 95%CI: -0.010 to -0.001) in multiple-adjusted models. In addition, changes in TL during the 5-year intervention were inversely associated with changes in the four anthropometric variables. The reduction in adiposity indices during the intervention, associated with increasing TL, was even higher among subjects with the longest telomeres at baseline. Logistic regression analysis showed that the risk of remaining obese after 5 years was lower in those participants who initially had the longest telomeres and increased their TL after intervention (OR=0.27, 95%CI: 0.03 to 2.03). Conclusions: Our research suggests that TL is inversely associated with changes in obesity parameters. The assessment of TL can provide further insights for biological pathways leading to adiposity. We show for the first time an improvement of obesity indices when an increase in TL is observed after a 5-year Mediterranean diet intervention. 2014-11-04T12:51:53Z 2014-11-04T12:51:53Z 2013-05-06 info:eu-repo/semantics/article https://hdl.handle.net/10171/37017 eng Research relating to this work was funded by grants from Línea Especial, Nutrición, Obesidad y Salud of the University of Navarra (LE/97), the Spanish Government (FIS-ISCIII: PI050976, PI070240, PI081943, PI1002293, RTIC 06/0045, CIBERobn, CNIC/06, SAF-2010-20367) and the Government of Navarra (PI41/2005, PI79/2006, PI36/2008, PI54/2009). The FPU fellowships to Sonia García-Calzón and to Alfredo Gea from the Spanish Ministry of Education, Culture and Sport are fully acknowledged. info:eu-repo/semantics/openAccess application/pdf Nature Publishing Group |
| spellingShingle | Telomere length Adiposity Aging Nutritional intervention Garcia-Calzon, S. (Sonia) Gea, A. (Alfredo) Razquin, C. (Cristina) Corella, D. (Dolores) Lamuela-Raventos, R.M. (Rosa Maria) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Zalba, G. (Guillermo) Marti-del-Moral, A. (Amelia) Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title | Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title_full | Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title_fullStr | Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title_full_unstemmed | Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title_short | Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial |
| title_sort | longitudinal association of telomere length and obesity indices in an intervention study with a mediterranean diet: the predimed-navarra trial |
| topic | Telomere length Adiposity Aging Nutritional intervention |
| url | https://hdl.handle.net/10171/37017 |
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