Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population
Background & Aims: Oxidative stress and inflammation seem to be potential underlying mechanisms for telomere attrition. A lack of specific antioxidants is believed to increase free radical damage and a greater risk for telomere shortening. Our aim was to evaluate the relationship between diet an...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2014
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| Online Access: | https://hdl.handle.net/10171/37018 |
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| author | Marti-del-Moral, A. (Amelia) Zalba, G. (Guillermo) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Moleres, A. (Adriana) Garcia-Calzon, S. (Sonia) |
| author_facet | Marti-del-Moral, A. (Amelia) Zalba, G. (Guillermo) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Moleres, A. (Adriana) Garcia-Calzon, S. (Sonia) |
| author_sort | Marti-del-Moral, A. (Amelia) |
| collection | DSpace |
| description | Background & Aims: Oxidative stress and inflammation seem to be potential underlying mechanisms for telomere attrition. A lack of specific antioxidants is believed to increase free radical damage and a greater risk for telomere shortening. Our aim was to evaluate the relationship between diet and leukocyte telomere length in a cross-sectional study of children and adolescents. We hypothesized that dietary total antioxidant capacity would be positively associated with telomere length.
Methods: Telomere length was measured by quantitative real-time polymerase chain reaction in 287 participants (55% males, 6–18 years), who were randomly selected from the GENOI study.
Results: A positive correlation between dietary total antioxidant capacity and telomere length (r=0.157, p=0.007) was found after adjustment for age and energy intake. However, higher white bread consumption was associated with shorter telomeres (β=-0.204, p=0.002) in fully-adjusted models. Interestingly, those individuals who had simultaneously higher dietary total antioxidant capacity and lower white bread consumption significantly presented the longest telomeres. Moreover, the multivariable-adjusted odds ratio for very short telomeres was 0.30 for dietary total antioxidant capacity (p=0.023) and 1.37 for white bread (p=0.025).
Conclusion: It was concluded that longer telomeres were associated with higher dietary total antioxidant capacity and lower white bread consumption in S2panish children and adolescents. These findings might open a new line of investigation about the potential role of an antioxidant diet in maintaining telomere length. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-37018 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-370182024-01-24T08:58:36Z Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population Marti-del-Moral, A. (Amelia) Zalba, G. (Guillermo) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Moleres, A. (Adriana) Garcia-Calzon, S. (Sonia) Young population Telomeres Oxidative stress Diet Antioxidants Background & Aims: Oxidative stress and inflammation seem to be potential underlying mechanisms for telomere attrition. A lack of specific antioxidants is believed to increase free radical damage and a greater risk for telomere shortening. Our aim was to evaluate the relationship between diet and leukocyte telomere length in a cross-sectional study of children and adolescents. We hypothesized that dietary total antioxidant capacity would be positively associated with telomere length. Methods: Telomere length was measured by quantitative real-time polymerase chain reaction in 287 participants (55% males, 6–18 years), who were randomly selected from the GENOI study. Results: A positive correlation between dietary total antioxidant capacity and telomere length (r=0.157, p=0.007) was found after adjustment for age and energy intake. However, higher white bread consumption was associated with shorter telomeres (β=-0.204, p=0.002) in fully-adjusted models. Interestingly, those individuals who had simultaneously higher dietary total antioxidant capacity and lower white bread consumption significantly presented the longest telomeres. Moreover, the multivariable-adjusted odds ratio for very short telomeres was 0.30 for dietary total antioxidant capacity (p=0.023) and 1.37 for white bread (p=0.025). Conclusion: It was concluded that longer telomeres were associated with higher dietary total antioxidant capacity and lower white bread consumption in S2panish children and adolescents. These findings might open a new line of investigation about the potential role of an antioxidant diet in maintaining telomere length. 2014-11-04T12:58:12Z 2014-11-04T12:58:12Z 2014 info:eu-repo/semantics/article https://hdl.handle.net/10171/37018 eng Research relating to this work was funded by grants from Línea Especial, Nutrición, Obesidad y Salud of the University of Navarra (LE/97), the Spanish Government (FIS-ISCIII: PI050976, PI070240, PI081943, PI1002293, RTIC 06/0045, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, CNIC/06, SAF-2010-20367) and the Government of Navarra (PI41/2005, PI79/2006, PI36/2008, PI54/2009). info:eu-repo/semantics/openAccess image/tiff Elsevier |
| spellingShingle | Young population Telomeres Oxidative stress Diet Antioxidants Marti-del-Moral, A. (Amelia) Zalba, G. (Guillermo) Martinez, J.A. (José Alfredo) Martinez-Gonzalez, M.A. (Miguel Ángel) Moleres, A. (Adriana) Garcia-Calzon, S. (Sonia) Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title | Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title_full | Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title_fullStr | Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title_full_unstemmed | Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title_short | Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| title_sort | dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population |
| topic | Young population Telomeres Oxidative stress Diet Antioxidants |
| url | https://hdl.handle.net/10171/37018 |
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