A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk
Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between diet...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Public Library of Science
2014
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/37068 |
| _version_ | 1793400057955876864 |
|---|---|
| author | Castro-Quezada, I. (Itandehui) Sanchez-Villegas, A. (Almudena) Estruch, R. (Ramón) Salas-Salvado, J. (Jordi) Corella, D. (Dolores) Schröder, H. (Helmut) Alvarez Perez, J. (Jacqueline) Ruiz-López, M.D. (María Dolores) Artacho, R. (Reyes) Ros, E. (Emilio) Bullo, M. (Monica) Covas, M.I. (María Isabel) Ruiz-Gutierrez, V. (Valentina) Ruiz-Canela, M. (Miguel) Buil-Cosiales, P. (Pilar) Gomez-Gracia, E. (Enrique) Lapetra, J. (José) Pinto, X. (Xavier) Aros, F. (Fernando) Fiol, M. (Miquel) Lamuela-Raventos, R.M. (Rosa Maria) Martinez-Gonzalez, M.A. (Miguel Ángel) Serra-Majem, L. (Luis) |
| author_facet | Castro-Quezada, I. (Itandehui) Sanchez-Villegas, A. (Almudena) Estruch, R. (Ramón) Salas-Salvado, J. (Jordi) Corella, D. (Dolores) Schröder, H. (Helmut) Alvarez Perez, J. (Jacqueline) Ruiz-López, M.D. (María Dolores) Artacho, R. (Reyes) Ros, E. (Emilio) Bullo, M. (Monica) Covas, M.I. (María Isabel) Ruiz-Gutierrez, V. (Valentina) Ruiz-Canela, M. (Miguel) Buil-Cosiales, P. (Pilar) Gomez-Gracia, E. (Enrique) Lapetra, J. (José) Pinto, X. (Xavier) Aros, F. (Fernando) Fiol, M. (Miquel) Lamuela-Raventos, R.M. (Rosa Maria) Martinez-Gonzalez, M.A. (Miguel Ángel) Serra-Majem, L. (Luis) |
| author_sort | Castro-Quezada, I. (Itandehui) |
| collection | DSpace |
| description | Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL)
are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this
study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study.
Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular
prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was
collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each
item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact
with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression
models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of
energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs
and used Cox models with time-dependent exposures.
Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest
quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR = 2.15 (95% CI:
1.15–4.04); P for trend = 0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we
observed a similar association. Dietary GL was associated with all-causemortality only when subjects were younger than 75 years.
Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-37068 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-370682023-03-13T11:03:59Z A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk Castro-Quezada, I. (Itandehui) Sanchez-Villegas, A. (Almudena) Estruch, R. (Ramón) Salas-Salvado, J. (Jordi) Corella, D. (Dolores) Schröder, H. (Helmut) Alvarez Perez, J. (Jacqueline) Ruiz-López, M.D. (María Dolores) Artacho, R. (Reyes) Ros, E. (Emilio) Bullo, M. (Monica) Covas, M.I. (María Isabel) Ruiz-Gutierrez, V. (Valentina) Ruiz-Canela, M. (Miguel) Buil-Cosiales, P. (Pilar) Gomez-Gracia, E. (Enrique) Lapetra, J. (José) Pinto, X. (Xavier) Aros, F. (Fernando) Fiol, M. (Miquel) Lamuela-Raventos, R.M. (Rosa Maria) Martinez-Gonzalez, M.A. (Miguel Ángel) Serra-Majem, L. (Luis) Carbohydrates Diet Glycemic PREDIMED study Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR = 2.15 (95% CI: 1.15–4.04); P for trend = 0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-causemortality only when subjects were younger than 75 years. Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk. 2014-11-20T11:28:53Z 2014-11-20T11:28:53Z 2014 info:eu-repo/semantics/article https://hdl.handle.net/10171/37068 eng info:eu-repo/semantics/openAccess application/pdf Public Library of Science |
| spellingShingle | Carbohydrates Diet Glycemic PREDIMED study Castro-Quezada, I. (Itandehui) Sanchez-Villegas, A. (Almudena) Estruch, R. (Ramón) Salas-Salvado, J. (Jordi) Corella, D. (Dolores) Schröder, H. (Helmut) Alvarez Perez, J. (Jacqueline) Ruiz-López, M.D. (María Dolores) Artacho, R. (Reyes) Ros, E. (Emilio) Bullo, M. (Monica) Covas, M.I. (María Isabel) Ruiz-Gutierrez, V. (Valentina) Ruiz-Canela, M. (Miguel) Buil-Cosiales, P. (Pilar) Gomez-Gracia, E. (Enrique) Lapetra, J. (José) Pinto, X. (Xavier) Aros, F. (Fernando) Fiol, M. (Miquel) Lamuela-Raventos, R.M. (Rosa Maria) Martinez-Gonzalez, M.A. (Miguel Ángel) Serra-Majem, L. (Luis) A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title | A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title_full | A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title_fullStr | A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title_full_unstemmed | A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title_short | A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk |
| title_sort | high dietary glycemic index increases total mortality in a mediterranean population at high cardiovascular risk |
| topic | Carbohydrates Diet Glycemic PREDIMED study |
| url | https://hdl.handle.net/10171/37068 |
| work_keys_str_mv | AT castroquezadaiitandehui ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT sanchezvillegasaalmudena ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT estruchrramon ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT salassalvadojjordi ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT corelladdolores ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT schroderhhelmut ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT alvarezperezjjacqueline ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizlopezmdmariadolores ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT artachorreyes ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT roseemilio ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT bullommonica ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT covasmimariaisabel ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizgutierrezvvalentina ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizcanelammiguel ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT builcosialesppilar ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT gomezgraciaeenrique ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT lapetrajjose ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT pintoxxavier ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT arosffernando ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT fiolmmiquel ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT lamuelaraventosrmrosamaria ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT martinezgonzalezmamiguelangel ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT serramajemlluis ahighdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT castroquezadaiitandehui highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT sanchezvillegasaalmudena highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT estruchrramon highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT salassalvadojjordi highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT corelladdolores highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT schroderhhelmut highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT alvarezperezjjacqueline highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizlopezmdmariadolores highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT artachorreyes highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT roseemilio highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT bullommonica highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT covasmimariaisabel highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizgutierrezvvalentina highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT ruizcanelammiguel highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT builcosialesppilar highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT gomezgraciaeenrique highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT lapetrajjose highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT pintoxxavier highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT arosffernando highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT fiolmmiquel highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT lamuelaraventosrmrosamaria highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT martinezgonzalezmamiguelangel highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk AT serramajemlluis highdietaryglycemicindexincreasestotalmortalityinamediterraneanpopulationathighcardiovascularrisk |