A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk
Abstract Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk. Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres of...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Public Library of Science
2014
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| Online Access: | https://hdl.handle.net/10171/37085 |
| _version_ | 1793400035538370560 |
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| author | Guasch-Ferre, M. (Marta) Bullo, M. (Monica) Costa, B. (Bernardo) Martinez-Gonzalez, M.A. (Miguel Ángel) Ibarrola-Jurado, N. (Nuria) Estruch, R. (Ramón) Barrio, F. (Francisco) Salas-Salvado, J. (Jordi) |
| author_facet | Guasch-Ferre, M. (Marta) Bullo, M. (Monica) Costa, B. (Bernardo) Martinez-Gonzalez, M.A. (Miguel Ángel) Ibarrola-Jurado, N. (Nuria) Estruch, R. (Ramón) Barrio, F. (Francisco) Salas-Salvado, J. (Jordi) |
| author_sort | Guasch-Ferre, M. (Marta) |
| collection | DSpace |
| description | Abstract
Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean
population at high cardiovascular risk.
Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres
of the PREDIMED study (derivation sample). Multivariate Cox regression model ß-coefficients were used to weigh each risk
factor. PREDIMED-personal Score included body-mass-index, smoking status, family history of type 2 diabetes, alcohol
consumption and hypertension as categorical variables; PREDIMED-clinical Score included also high blood glucose. We
tested the predictive capability of these scores in the DE-PLAN-CAT cohort (validation sample). The discrimination of Finnish
Diabetes Risk Score (FINDRISC), German Diabetes Risk Score (GDRS) and our scores was assessed with the area under curve
(AUC).
Results: The PREDIMED-clinical Score varied from 0 to 14 points. In the subset of the PREDIMED study, 155 individuals
developed diabetes during the 4.75-years follow-up. The PREDIMED-clinical score at a cutoff of $6 had sensitivity of 72.2%,
and specificity of 72.5%, whereas AUC was 0.78. The AUC of the PREDIMED-clinical Score was 0.66 in the validation sample
(sensitivity = 85.4%; specificity = 26.6%), and was significantly higher than the FINDRISC and the GDRS in both the derivation
and validation samples.
Discussion: We identified classical risk factors for diabetes and developed the PREDIMED-clinical Score to determine those
individuals at high risk of developing diabetes in elderly individuals at high cardiovascular risk. The predictive capability of
the PREDIMED-clinical Score was significantly higher than the FINDRISC and GDRS, and also used fewer items in the
questionnaire. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-37085 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-370852022-06-29T09:41:38Z A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk Guasch-Ferre, M. (Marta) Bullo, M. (Monica) Costa, B. (Bernardo) Martinez-Gonzalez, M.A. (Miguel Ángel) Ibarrola-Jurado, N. (Nuria) Estruch, R. (Ramón) Barrio, F. (Francisco) Salas-Salvado, J. (Jordi) Life-style intervention Identifying individuals Glucose-tolerance Physical-activity Prevention Questionnaire Care Validation Project Adults Abstract Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk. Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres of the PREDIMED study (derivation sample). Multivariate Cox regression model ß-coefficients were used to weigh each risk factor. PREDIMED-personal Score included body-mass-index, smoking status, family history of type 2 diabetes, alcohol consumption and hypertension as categorical variables; PREDIMED-clinical Score included also high blood glucose. We tested the predictive capability of these scores in the DE-PLAN-CAT cohort (validation sample). The discrimination of Finnish Diabetes Risk Score (FINDRISC), German Diabetes Risk Score (GDRS) and our scores was assessed with the area under curve (AUC). Results: The PREDIMED-clinical Score varied from 0 to 14 points. In the subset of the PREDIMED study, 155 individuals developed diabetes during the 4.75-years follow-up. The PREDIMED-clinical score at a cutoff of $6 had sensitivity of 72.2%, and specificity of 72.5%, whereas AUC was 0.78. The AUC of the PREDIMED-clinical Score was 0.66 in the validation sample (sensitivity = 85.4%; specificity = 26.6%), and was significantly higher than the FINDRISC and the GDRS in both the derivation and validation samples. Discussion: We identified classical risk factors for diabetes and developed the PREDIMED-clinical Score to determine those individuals at high risk of developing diabetes in elderly individuals at high cardiovascular risk. The predictive capability of the PREDIMED-clinical Score was significantly higher than the FINDRISC and GDRS, and also used fewer items in the questionnaire. 2014-11-24T11:07:23Z 2014-11-24T11:07:23Z 2012 info:eu-repo/semantics/article https://hdl.handle.net/10171/37085 eng info:eu-repo/semantics/openAccess application/pdf Public Library of Science |
| spellingShingle | Life-style intervention Identifying individuals Glucose-tolerance Physical-activity Prevention Questionnaire Care Validation Project Adults Guasch-Ferre, M. (Marta) Bullo, M. (Monica) Costa, B. (Bernardo) Martinez-Gonzalez, M.A. (Miguel Ángel) Ibarrola-Jurado, N. (Nuria) Estruch, R. (Ramón) Barrio, F. (Francisco) Salas-Salvado, J. (Jordi) A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title_full | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title_fullStr | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title_full_unstemmed | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title_short | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| title_sort | risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk |
| topic | Life-style intervention Identifying individuals Glucose-tolerance Physical-activity Prevention Questionnaire Care Validation Project Adults |
| url | https://hdl.handle.net/10171/37085 |
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