Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso
The increasing prevalence of childhood obesity makes necessary to intensify obesity treatment. A successful weight loss programme in overweight and obese children and adolescents should be accompanied by a general metabolic improvement and a reduction in several cardiovascular risk factors. The aim...
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | spa |
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Servicio de Publicaciones de la Universidad de Navarra
2015
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| Online Access: | https://hdl.handle.net/10171/37384 |
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| author | Rendo-Urteaga, T. (Tara) Marti-del-Moral, A. (Amelia) Martinez, J.A. (José Alfredo) |
| author_facet | Rendo-Urteaga, T. (Tara) Marti-del-Moral, A. (Amelia) Martinez, J.A. (José Alfredo) |
| author_sort | Rendo-Urteaga, T. (Tara) |
| collection | DSpace |
| description | The increasing prevalence of childhood obesity makes necessary to intensify obesity treatment. A successful weight loss programme in overweight and obese children and adolescents should be accompanied by a general metabolic improvement and a reduction in several cardiovascular risk factors. The aim of this study was to evaluate the effect of a 10-week intervention program, based on a moderate calorie restriction on metabolic and oxidative stress markers and gene expression profile in peripheral blood mononuclear cells (PBMC) from obese children. For this purpose, forty-four overweight/obese children (mean age 11.5 years; 50% males) were enrolled in a 10-week weight loss programme. Subjects were dichotomized by the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change as high (HR) and low responders (LR) at the end of the weight loss programme. These results suggest that a lower decrease in dietary total antioxidant capacity (TAC) after the intervention may predict a greater weight loss in obese children with a good response to the diet. Furthermore, a better serum antioxidant-oxidant balance before a weight loss treatment could predict a better weight loss response. On the other hand, we showed, for the first time, a reduction in serum cardiotrophin-1 levels after a weight loss programme and that this decrease in cardiotrophin-1 was strongly associated with lower cholesterol levels in overweight/obese children. Finally, the study confirms that PBMC gene expression changes in obese boys may help to understand the weight loss response. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-37384 |
| institution | Universidad de Navarra |
| language | spa |
| publishDate | 2015 |
| publisher | Servicio de Publicaciones de la Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-373842024-01-24T08:58:37Z Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso Rendo-Urteaga, T. (Tara) Marti-del-Moral, A. (Amelia) Martinez, J.A. (José Alfredo) Ciencias de la nutrición Población infantil Materias Investigacion::Farmacia Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Niños Genética humana The increasing prevalence of childhood obesity makes necessary to intensify obesity treatment. A successful weight loss programme in overweight and obese children and adolescents should be accompanied by a general metabolic improvement and a reduction in several cardiovascular risk factors. The aim of this study was to evaluate the effect of a 10-week intervention program, based on a moderate calorie restriction on metabolic and oxidative stress markers and gene expression profile in peripheral blood mononuclear cells (PBMC) from obese children. For this purpose, forty-four overweight/obese children (mean age 11.5 years; 50% males) were enrolled in a 10-week weight loss programme. Subjects were dichotomized by the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change as high (HR) and low responders (LR) at the end of the weight loss programme. These results suggest that a lower decrease in dietary total antioxidant capacity (TAC) after the intervention may predict a greater weight loss in obese children with a good response to the diet. Furthermore, a better serum antioxidant-oxidant balance before a weight loss treatment could predict a better weight loss response. On the other hand, we showed, for the first time, a reduction in serum cardiotrophin-1 levels after a weight loss programme and that this decrease in cardiotrophin-1 was strongly associated with lower cholesterol levels in overweight/obese children. Finally, the study confirms that PBMC gene expression changes in obese boys may help to understand the weight loss response. 2015-01-29T17:16:13Z 2015-01-29T17:16:13Z 2015 2012-12-12 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/37384 spa info:eu-repo/semantics/openAccess application/pdf Servicio de Publicaciones de la Universidad de Navarra |
| spellingShingle | Ciencias de la nutrición Población infantil Materias Investigacion::Farmacia Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Niños Genética humana Rendo-Urteaga, T. (Tara) Marti-del-Moral, A. (Amelia) Martinez, J.A. (José Alfredo) Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title_full | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title_fullStr | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title_full_unstemmed | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title_short | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| title_sort | perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso |
| topic | Ciencias de la nutrición Población infantil Materias Investigacion::Farmacia Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Niños Genética humana |
| url | https://hdl.handle.net/10171/37384 |
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