Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives

Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives

A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships de...

書誌詳細
主要な著者:	Burguete, A. (Asunción), Estevez, Y. (Yannick), Castillo, D. (Denis), Gonzalez, G. (Germán), Raquel, Solano, B. (Beatriz), Vicente, E. (Esther), Pérez-Silanes, S. (Silvia), Aldana, I. (Ignacio), Monge, A. (Antonio), Sauvain, M. (Michel), Deharo, E. (Eric)
フォーマット:	info:eu-repo/semantics/article
言語:	eng
出版事項:	Instituto Oswaldo Cruz, Ministério da Saúde 2015
主題:	Quinoxaline Anti-leishmanial Structure-activity Leishmaniasis
オンライン･アクセス:	https://hdl.handle.net/10171/37636

類似資料

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
著者:: Barea, C. (Carlos), 等
出版事項: (2012)

Cyclic voltammetric study of some anti-Chagas-active 1,4-dioxidoquinoxalin-2-yl ketone derivatives
著者:: Crawford, P.W. (Philip W.), 等
出版事項: (2014)

Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.
著者:: Vicente, E. (Esther), 等
出版事項: (2012)

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.
著者:: Ancizu, S. (Saioa), 等
出版事項: (2012)

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis
著者:: Vicente, E. (Esther), 等
出版事項: (2013)

Synthesis and antimycobacterial activity of new quinoxaline-2- carboxamide 1,4-di-N-oxide derivatives.
著者:: Monge, A. (Antonio), 等
出版事項: (2014)

New quinoxaline 1,4-di-N-oxide derivatives: Trypanosomaticidal activities and enzyme docking simulation
著者:: Estevez, Y. (Yannick), 等
出版事項: (2014)

Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis
著者:: Vicente, E. (Esther), 等
出版事項: (2011)

New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
著者:: Barea, C. (Carlos), 等
出版事項: (2013)

New quinoxaline and indole derivatives as MT1 and MT2 receptor agonists
著者:: Ancizu, S. (Saioa), 等
出版事項: (2014)

Synthesis of quinoxaline 1,4-di-N-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures
著者:: Gomez-Caro, L.C. (Lilia C.), 等
出版事項: (2013)

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents
著者:: Torres, E. (Enrique), 等
出版事項: (2011)

Unexpected reduction of ethyl 3-phenylquinoxaline-2- carboxylate 1,4-di-N-oxide derivatives by amines.
著者:: Lima, L.M. (Lidia M.), 等
出版事項: (2012)

Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives
著者:: Vicente, E. (Esther), 等
出版事項: (2012)

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents
著者:: Pérez-Silanes, S. (Silvia), 等
出版事項: (2014)

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
著者:: Aldana, I. (Ignacio), 等
出版事項: (2014)

Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis
著者:: Santivañez-Veliz, M. (Mery), 等
出版事項: (2016)

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti- Mycobacterium tuberculosis agents.
著者:: Monge, A. (Antonio), 等
出版事項: (2014)

Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.
著者:: Moreno-de-Viguri, E. (Elsa), 等
出版事項: (2012)

Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives
著者:: Zarranz, B. (Belén), 等
出版事項: (2013)

Primaquine–quinoxaline 1,4‑di‑N‑oxide hybrids with action on the exo‑erythrocytic forms of Plasmodium induce their efect by the production of reactive oxygen species
著者:: Bonilla‑Ramírez, L. (Leonardo), 等
出版事項: (2022)

Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
著者:: Barea, C. (Carlos), 等
出版事項: (2012)

Derivados de 1,4-di-N-óxido de quinoxalina y enfermedades olvidadas
著者:: Vicente, E. (Esther), 等
出版事項: (2013)

Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
著者:: Burguete, A. (Asunción), 等
出版事項: (2011)

Leishmaniasis en Navarra (1976-2018): actualización
著者:: Burguete-Mikeo, A. (Aroia), 等
出版事項: (2022)

Leishmaniasis en nuestro medio
著者:: Marín P., Enrique, 等
出版事項: (2014)

Dibromoethane:1,2

Dichloropropene, 1,3 : dichlopropane and Mixtures, 1,2

Studies on LogP o/w of Quinoxaline di-N-osides: a comparison of RP-HPLC experimental and predictive approaches
著者:: Moreno-de-Viguri, E. (Elsa), 等
出版事項: (2012)

New 1-aryl-3-substituted propanol derivatives as antimalarial agents
著者:: Pérez-Silanes, S. (Silvia), 等
出版事項: (2012)

El Humanscale 1/2

Symphony no. 1, symphony no. 2
著者:: Terterian, Avet 1929-1994

Canto 1 y 2
著者:: Soler Cañas, Luis

Cuentos 1 y 2

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity
著者:: Pérez-Silanes, S. (Silvia), 等
出版事項: (2016)

The BRCT domain from the homologue of the oncogene PES1 in Leishmania major (LmjPES) promotes malignancy and drug resistance in mammalian cells
著者:: Larrea, E. (Esther), 等
出版事項: (2022)

Informática 1-2 Administración y secretariado
著者:: Llansana, Jaume

Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
著者:: Moreno-de-Viguri, E. (Elsa), 等
出版事項: (2013)

LmjF.22.0810 from Leishmania major Modulates the Th2-Type Immune Response and Is Involved in Leishmaniasis Outcome
著者:: Vacas, A. (Andrés), 等
出版事項: (2023)

3-Trifluoromethylquinoxaline N,N’-Dioxides as Anti-trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Derivatives and Mechanism of Action Studies
著者:: Benitez, D. (Diego), 等
出版事項: (2011)